 |
 |
|
| 30.10.2021 | 16:00 | Club León | - | Atlético San Luis | 2:1 (1:0) | |
| 16:00 | Santos Laguna | - | Club Necaxa | 2:1 (2:0) | ||
| 17:00 | Pumas UNAM | - | Cruz Azul | 2:0 (1:0) | ||
| 18:00 | Mazatlán FC | - | Atlas Guadalajara | 1:3 (1:2) | ||
| 19:00 | Club Tijuana | - | Gallos Blancos | 3:2 (1:1) | ||
| 23:00 | CF América | - | Deportivo Toluca | 0:3 (0:1) | ||
| 23:00 | Puebla FC | - | FC Juárez | 2:1 (1:0) | ||
| 23:00 | CF Monterrey | - | Deportivo Guadalajara | 1:7 (1:3) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 13 | 9 | 3 | 1 | 43:15 | 28 | 30 |
| 2 |
|
Pumas UNAM | 13 | 9 | 2 | 2 | 23:10 | 13 | 29 |
| 3 |
|
Deportivo Toluca | 14 | 8 | 5 | 1 | 23:13 | 10 | 29 |
| 4 |
|
Santos Laguna | 13 | 8 | 4 | 1 | 29:14 | 15 | 28 |
| 5 |
|
CF Pachuca | 13 | 7 | 3 | 3 | 16:11 | 5 | 24 |
| 6 |
|
Cruz Azul | 14 | 7 | 3 | 4 | 18:15 | 3 | 24 |
| 7 |
|
UANL Tigres | 13 | 6 | 3 | 4 | 21:16 | 5 | 21 |
| 8 |
|
Club Necaxa | 13 | 6 | 2 | 5 | 21:15 | 6 | 20 |
| 9 |
|
Atlas Guadalajara | 13 | 6 | 1 | 6 | 31:26 | 5 | 19 |
| 10 |
|
CF Monterrey | 14 | 5 | 4 | 5 | 21:24 | -3 | 19 |
| 11 |
|
Club Tijuana | 13 | 6 | 1 | 6 | 17:20 | -3 | 19 |
| 12 |
|
Club León | 13 | 5 | 3 | 5 | 20:20 | 0 | 18 |
| 13 |
|
Puebla FC | 13 | 4 | 3 | 6 | 21:24 | -3 | 15 |
| 14 |
|
CF América | 13 | 4 | 1 | 8 | 18:21 | -3 | 13 |
| 15 |
|
Gallos Blancos | 14 | 2 | 4 | 8 | 16:21 | -5 | 10 |
| 16 |
|
Mazatlán FC | 14 | 3 | 1 | 10 | 21:45 | -24 | 10 |
| 17 |
|
FC Juárez | 13 | 1 | 2 | 10 | 9:26 | -17 | 5 |
| 18 |
|
Atlético San Luis | 14 | 1 | 1 | 12 | 10:42 | -32 | 4 |
| Play-offs |
