 |
 |
|
| 31.07.2021 | 16:00 | UANL Tigres | - | Club León | 3:1 (3:1) | |
| 17:00 | Pumas UNAM | - | CF América | 2:1 (1:1) | ||
| 17:00 | Deportivo Guadalajara | - | CF Monterrey | 2:0 (2:0) | ||
| 18:00 | CF Pachuca | - | Cruz Azul | 1:2 (0:0) | ||
| 18:00 | Mazatlán FC | - | Atlético San Luis | 4:0 (3:0) | ||
| 19:00 | Gallos Blancos | - | Puebla FC | 2:1 (2:1) | ||
| 15.09.2021 | 19:00 | Club Tijuana | - | Deportivo Toluca | 3:0 (2:0) | |
| 05.10.2021 | 19:00 | Club Necaxa | - | Atlas Guadalajara | 0:1 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlas Guadalajara | 2 | 2 | 0 | 0 | 7:1 | 6 | 6 |
| 2 |
|
Deportivo Guadalajara | 2 | 2 | 0 | 0 | 6:2 | 4 | 6 |
| 3 |
|
Cruz Azul | 2 | 1 | 1 | 0 | 2:1 | 1 | 4 |
|
Pumas UNAM | 2 | 1 | 1 | 0 | 2:1 | 1 | 4 | |
| 5 |
|
Club Tijuana | 1 | 1 | 0 | 0 | 3:0 | 3 | 3 |
| 6 |
|
UANL Tigres | 1 | 1 | 0 | 0 | 3:1 | 2 | 3 |
| 7 |
|
CF América | 2 | 1 | 0 | 1 | 3:2 | 1 | 3 |
| 8 |
|
CF Pachuca | 2 | 1 | 0 | 1 | 4:4 | 0 | 3 |
| 9 |
|
Mazatlán FC | 2 | 1 | 0 | 1 | 5:6 | -1 | 3 |
| 10 |
|
Gallos Blancos | 2 | 1 | 0 | 1 | 2:3 | -1 | 3 |
| 11 |
|
Deportivo Toluca | 2 | 1 | 0 | 1 | 2:4 | -2 | 3 |
| 12 |
|
Santos Laguna | 1 | 0 | 1 | 0 | 4:4 | 0 | 1 |
| 13 |
|
Club Necaxa | 2 | 0 | 1 | 1 | 1:2 | -1 | 1 |
| 14 |
|
CF Monterrey | 2 | 0 | 1 | 1 | 4:6 | -2 | 1 |
| 15 |
|
Club León | 2 | 0 | 1 | 1 | 2:4 | -2 | 1 |
| 16 |
|
FC Juárez | 1 | 0 | 0 | 1 | 1:2 | -1 | 0 |
| 17 |
|
Puebla FC | 2 | 0 | 0 | 2 | 3:5 | -2 | 0 |
| 18 |
|
Atlético San Luis | 2 | 0 | 0 | 2 | 2:8 | -6 | 0 |
| Play-offs |
