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| 29.01.2022 | 15:00 | Atlético San Luis | - | Atlas Guadalajara | 0:1 (0:1) | |
| 16:00 | Deportivo Toluca | - | Pumas UNAM | 2:0 (2:0) | ||
| 16:00 | Santos Laguna | - | Deportivo Guadalajara | 0:1 (0:0) | ||
| 16:00 | UANL Tigres | - | Club Tijuana | 3:0 (1:0) | ||
| 16:00 | CF Monterrey | - | Mazatlán FC | 2:2 (2:0) | ||
| 17:00 | Cruz Azul | - | Gallos Blancos | 2:0 (1:0) | ||
| 17:00 | FC Juárez | - | Club Necaxa | 1:1 (0:1) | ||
| 18:00 | CF Pachuca | - | CF América | 0:3 (0:3) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 4 | 4 | 0 | 0 | 8:0 | 8 | 12 |
| 2 |
|
Cruz Azul | 4 | 3 | 0 | 1 | 9:5 | 4 | 9 |
| 3 |
|
Deportivo Toluca | 4 | 2 | 1 | 1 | 12:6 | 6 | 7 |
| 4 |
|
Puebla FC | 3 | 1 | 1 | 1 | 4:3 | 1 | 4 |
| 5 |
|
FC Juárez | 3 | 1 | 1 | 1 | 4:5 | -1 | 4 |
| 6 |
|
Club Necaxa | 3 | 1 | 1 | 1 | 4:9 | -5 | 4 |
| 7 |
|
Pumas UNAM | 4 | 1 | 0 | 3 | 4:5 | -1 | 3 |
| 8 |
|
CF Pachuca | 3 | 0 | 1 | 2 | 4:9 | -5 | 1 |
| 9 |
|
Gallos Blancos | 4 | 0 | 1 | 3 | 2:9 | -7 | 1 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlas Guadalajara | 4 | 3 | 1 | 0 | 7:2 | 5 | 10 |
| 2 |
|
Deportivo Guadalajara | 4 | 2 | 2 | 0 | 6:4 | 2 | 8 |
| 3 |
|
UANL Tigres | 3 | 2 | 0 | 1 | 4:2 | 2 | 6 |
| 4 |
|
Santos Laguna | 3 | 1 | 1 | 1 | 2:1 | 1 | 4 |
| 5 |
|
CF Monterrey | 4 | 0 | 4 | 0 | 6:6 | 0 | 4 |
| 6 |
|
Mazatlán FC | 3 | 1 | 1 | 1 | 4:4 | 0 | 4 |
| 7 |
|
Club Tijuana | 4 | 1 | 1 | 2 | 4:8 | -4 | 4 |
| 8 |
|
Club León | 3 | 0 | 1 | 2 | 3:5 | -2 | 1 |
| 9 |
|
Atlético San Luis | 4 | 0 | 1 | 3 | 2:6 | -4 | 1 |
| Play-offs | |
| Play-offs |
