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| 18.02.2022 | 16:00 | Club León | - | Santos Laguna | 0:0 (0:0) | |
| 19.02.2022 | 16:00 | Atlas Guadalajara | - | UANL Tigres | 1:1 (1:0) | |
| 16:00 | Deportivo Guadalajara | - | Mazatlán FC | 7:1 (3:0) | ||
| 17:00 | FC Juárez | - | Cruz Azul | 1:2 (1:1) | ||
| 18:00 | CF Pachuca | - | Gallos Blancos | 5:1 (4:0) | ||
| 19:00 | Club Tijuana | - | CF Monterrey | 1:0 (1:0) | ||
| 23:00 | CF América | - | Club Necaxa | 3:2 (2:1) | ||
| 23:00 | Puebla FC | - | Pumas UNAM | 0:1 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cruz Azul | 6 | 5 | 0 | 1 | 15:6 | 9 | 15 |
| 2 |
|
CF América | 6 | 5 | 0 | 1 | 11:3 | 8 | 15 |
| 3 |
|
Pumas UNAM | 7 | 4 | 0 | 3 | 10:5 | 5 | 12 |
| 4 |
|
Deportivo Toluca | 6 | 3 | 1 | 2 | 14:11 | 3 | 10 |
| 5 |
|
FC Juárez | 6 | 2 | 1 | 3 | 7:9 | -2 | 7 |
| 6 |
|
Club Necaxa | 6 | 1 | 3 | 2 | 8:14 | -6 | 6 |
| 7 |
|
Puebla FC | 6 | 1 | 2 | 3 | 5:6 | -1 | 5 |
| 8 |
|
CF Pachuca | 6 | 1 | 2 | 3 | 11:16 | -5 | 5 |
| 9 |
|
Gallos Blancos | 7 | 1 | 1 | 5 | 5:16 | -11 | 4 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 6 | 4 | 2 | 0 | 14:5 | 9 | 14 |
| 2 |
|
Atlas Guadalajara | 6 | 3 | 2 | 1 | 11:8 | 3 | 11 |
| 3 |
|
UANL Tigres | 6 | 3 | 2 | 1 | 8:5 | 3 | 11 |
| 4 |
|
Club Tijuana | 7 | 3 | 1 | 3 | 7:10 | -3 | 10 |
| 5 |
|
Santos Laguna | 6 | 2 | 2 | 2 | 8:6 | 2 | 8 |
| 6 |
|
Club León | 6 | 2 | 2 | 2 | 6:6 | 0 | 8 |
| 7 |
|
Mazatlán FC | 6 | 1 | 2 | 3 | 8:15 | -7 | 5 |
| 8 |
|
CF Monterrey | 7 | 0 | 4 | 3 | 6:9 | -3 | 4 |
| 9 |
|
Atlético San Luis | 6 | 1 | 1 | 4 | 5:9 | -4 | 4 |
| Play-offs | |
| Play-offs |
