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| 23.07.2022 | 16:00 | Puebla FC | - | Cruz Azul | 0:4 (0:3) | |
| 16:00 | Atlas Guadalajara | - | Atlético San Luis | 1:1 (0:0) | ||
| 16:00 | Santos Laguna | - | Mazatlán FC | 2:1 (1:0) | ||
| 16:00 | Club León | - | Club Tijuana | 1:2 (1:1) | ||
| 16:00 | UANL Tigres | - | CF Monterrey | 0:2 (0:0) | ||
| 17:00 | FC Juárez | - | Deportivo Toluca | 0:4 (0:3) | ||
| 19:00 | CF Pachuca | - | Club Necaxa | 1:1 (0:0) | ||
| 24.07.2022 | 18:00 | CF América | - | Gallos Blancos | 3:2 (2:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 5 | 3 | 1 | 1 | 8:7 | 1 | 10 |
| 2 |
|
Club Necaxa | 4 | 2 | 2 | 0 | 14:5 | 9 | 8 |
| 3 |
|
Deportivo Toluca | 4 | 2 | 1 | 1 | 12:6 | 6 | 7 |
| 4 |
|
CF América | 4 | 2 | 1 | 1 | 8:7 | 1 | 7 |
| 5 |
|
Cruz Azul | 5 | 1 | 2 | 2 | 10:8 | 2 | 5 |
| 6 |
|
Pumas UNAM | 4 | 1 | 2 | 1 | 3:5 | -2 | 5 |
| 7 |
|
FC Juárez | 5 | 1 | 2 | 2 | 5:9 | -4 | 5 |
| 8 |
|
Gallos Blancos | 5 | 1 | 1 | 3 | 5:12 | -7 | 4 |
| 9 |
|
Puebla FC | 4 | 0 | 2 | 2 | 4:10 | -6 | 2 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Santos Laguna | 5 | 4 | 0 | 1 | 10:6 | 4 | 12 |
| 2 |
|
Deportivo Guadalajara | 4 | 3 | 0 | 1 | 9:5 | 4 | 9 |
| 3 |
|
CF Monterrey | 5 | 3 | 0 | 2 | 9:7 | 2 | 9 |
| 4 |
|
Mazatlán FC | 4 | 2 | 1 | 1 | 6:5 | 1 | 7 |
| 5 |
|
Club Tijuana | 5 | 2 | 1 | 2 | 5:4 | 1 | 7 |
| 6 |
|
Atlas Guadalajara | 5 | 2 | 1 | 2 | 5:6 | -1 | 7 |
| 7 |
|
Atlético San Luis | 4 | 1 | 1 | 2 | 7:8 | -1 | 4 |
| 8 |
|
UANL Tigres | 4 | 1 | 0 | 3 | 2:7 | -5 | 3 |
| 9 |
|
Club León | 4 | 0 | 0 | 4 | 3:8 | -5 | 0 |
| Play-offs | |
| Play-offs |
