 |
 |
| U | Cruz Azul | - | Atlas Guadalajara | 0:4 (0:3) | ||
| R | Atlas Guadalajara | - | Cruz Azul | 0:3 (0:2) | ||
| U: 05.05.2021 16:00 | R: 08.05.2021 16:00 | Winnaars: Atlas Guadalajara | ||||
| U | Santos Laguna | - | Pumas UNAM | 0:0 (0:0) | ||
| R | Pumas UNAM | - | Santos Laguna | 1:1 (0:0) | ||
| U: 05.05.2021 16:00 | R: 08.05.2021 18:00 | Winnaars: Santos Laguna | ||||
| U | Deportivo Toluca | - | CF Pachuca | 2:2 (1:1) | ||
| R | CF Pachuca | - | Deportivo Toluca | 2:0 (2:0) | ||
| U: 05.05.2021 18:30 | R: 08.05.2021 16:30 | Winnaars: CF Pachuca | ||||
| U | Deportivo Guadalajara | - | Club León | 0:0 (0:0) | ||
| R | Club León | - | Deportivo Guadalajara | 1:1 (0:1) | ||
| U: 06.05.2021 17:00 | R: 09.05.2021 18:30 | Winnaars: Deportivo Guadalajara | ||||
