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| U | Pumas UNAM | - | Atlas Guadalajara | 3:2 (2:2) | ||
| R | Atlas Guadalajara | - | Pumas UNAM | 4:0 (0:0) | ||
| U: 11.05.2022 17:00 | R: 14.05.2022 16:00 | Winnaars: Atlas Guadalajara | ||||
| U | Club Tijuana | - | Santos Laguna | 1:1 (0:0) | ||
| R | Santos Laguna | - | Club Tijuana | 4:1 (1:1) | ||
| U: 12.05.2022 21:45 | R: 15.05.2022 17:00 | Winnaars: Santos Laguna | ||||
