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| U | Monarcas Morelia | - | CF Monterrey | 1:2 (0:1) | ||
| R | CF Monterrey | - | Monarcas Morelia | 2:0 (0:0) | ||
| U: 08.05.2019 17:00 | R: 11.05.2019 16:00 | Winnaars: CF Monterrey | ||||
| U | CF América | - | Atlas Guadalajara | 1:2 (0:1) | ||
| R | Atlas Guadalajara | - | CF América | 1:0 (1:0) | ||
| U: 08.05.2019 18:00 | R: 11.05.2019 17:00 | Winnaars: Atlas Guadalajara | ||||
| U | UANL Tigres | - | CF Pachuca | 2:1 (0:0) | ||
| R | CF Pachuca | - | UANL Tigres | 2:2 (0:0) | ||
| U: 08.05.2019 18:00 | R: 12.05.2019 00:00 | Winnaars: UANL Tigres | ||||
| U | Deportivo Toluca | - | Santos Laguna | 2:1 (1:0) | ||
| R | Santos Laguna | - | Deportivo Toluca | 2:0 (1:0) | ||
| U: 09.05.2019 16:00 | R: 12.05.2019 18:15 | Winnaars: Santos Laguna | ||||
