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| U | Atlas Guadalajara | - | CF América | 3:1 (2:0) | ||
| R | CF América | - | Atlas Guadalajara | 0:2 (0:0) | ||
| U: 05.05.2021 16:00 | R: 08.05.2021 18:00 | Winnaars: Atlas Guadalajara | ||||
| U | Club León | - | CF Monterrey | 0:1 (0:1) | ||
| R | CF Monterrey | - | Club León | 3:2 (3:1) | ||
| U: 05.05.2021 17:00 | R: 08.05.2021 16:00 | Winnaars: CF Monterrey | ||||
| U | Deportivo Toluca | - | Club Tijuana | 1:0 (1:0) | ||
| R | Club Tijuana | - | Deportivo Toluca | 2:2 (1:0) | ||
| U: 06.05.2021 16:00 | R: 10.05.2021 06:00 | Winnaars: Deportivo Toluca | ||||
| U | FC Juárez | - | CF Pachuca | 1:1 (1:0) | ||
| R | CF Pachuca | - | FC Juárez | 0:0 (0:0) | ||
| U: 06.05.2021 18:00 | R: 09.05.2021 19:00 | Winnaars: CF Pachuca | ||||
