 |
 |
|
|
| 01.04.2022 | 17:00 | Atlético San Luis | - | Mazatlán FC | 1:2 (0:1) | |
| 02.04.2022 | 17:00 | Club Necaxa | - | CF América | 1:2 (0:0) | |
| 17:00 | Cruz Azul | - | Atlas Guadalajara | 1:0 (1:0) | ||
| 17:00 | Deportivo Guadalajara | - | CF Monterrey | 2:1 (1:1) | ||
| 17:00 | FC Juárez | - | Pumas UNAM | 3:2 (0:1) | ||
| 03.04.2022 | 17:00 | Deportivo Toluca | - | Puebla FC | 2:0 (0:0) | |
| 17:00 | Club León | - | Gallos Blancos | 2:1 (0:0) | ||
| 17:00 | UANL Tigres | - | Club Tijuana | 1:2 (1:0) | ||
| 19:00 | Santos Laguna | - | CF Pachuca | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 12 | 8 | 1 | 3 | 22:13 | 9 | 25 |
|
Club León | 12 | 8 | 1 | 3 | 22:13 | 9 | 25 | |
| 3 |
|
Club Tijuana | 12 | 7 | 2 | 3 | 19:15 | 4 | 23 |
| 4 |
|
Deportivo Guadalajara | 12 | 7 | 2 | 3 | 14:12 | 2 | 23 |
| 5 |
|
CF América | 12 | 7 | 1 | 4 | 21:11 | 10 | 22 |
| 6 |
|
Deportivo Toluca | 12 | 6 | 3 | 3 | 19:14 | 5 | 21 |
| 7 |
|
Santos Laguna | 12 | 6 | 2 | 4 | 15:16 | -1 | 20 |
| 8 |
|
Atlético San Luis | 12 | 6 | 1 | 5 | 26:18 | 8 | 19 |
| 9 |
|
UANL Tigres | 12 | 5 | 2 | 5 | 20:15 | 5 | 17 |
| 10 |
|
Cruz Azul | 12 | 4 | 4 | 4 | 12:10 | 2 | 16 |
| 11 |
|
Club Necaxa | 12 | 5 | 1 | 6 | 18:18 | 0 | 16 |
| 12 |
|
Mazatlán FC | 12 | 5 | 1 | 6 | 14:19 | -5 | 16 |
| 13 |
|
Pumas UNAM | 12 | 4 | 3 | 5 | 14:13 | 1 | 15 |
| 14 |
|
CF Monterrey | 12 | 4 | 3 | 5 | 14:20 | -6 | 15 |
| 15 |
|
FC Juárez | 12 | 2 | 4 | 6 | 12:24 | -12 | 10 |
| 16 |
|
Atlas Guadalajara | 12 | 2 | 3 | 7 | 8:17 | -9 | 9 |
| 17 |
|
Puebla FC | 12 | 2 | 1 | 9 | 11:26 | -15 | 7 |
| 18 |
|
Gallos Blancos | 12 | 1 | 3 | 8 | 6:13 | -7 | 6 |
| Play-offs |
