 |
 |
|
| 29.04.2022 | 16:00 | Club Necaxa | - | Deportivo Guadalajara | 0:3 (0:1) | |
| 17:00 | Mazatlán FC | - | Puebla FC | 4:1 (0:0) | ||
| 30.04.2022 | 16:00 | Gallos Blancos | - | FC Juárez | 0:0 (0:0) | |
| 16:00 | Atlas Guadalajara | - | UANL Tigres | 0:0 (0:0) | ||
| 16:00 | CF Monterrey | - | Club Tijuana | 3:0 (2:0) | ||
| 16:00 | CF América | - | Cruz Azul | 2:0 (1:0) | ||
| 01.05.2022 | 16:00 | Pumas UNAM | - | CF Pachuca | 2:1 (0:0) | |
| 16:00 | Atlético San Luis | - | Santos Laguna | 2:2 (0:0) | ||
| 16:00 | Club León | - | Deportivo Toluca | 3:1 (2:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club León | 17 | 11 | 2 | 4 | 34:18 | 16 | 35 |
| 2 |
|
CF Pachuca | 17 | 10 | 3 | 4 | 31:17 | 14 | 33 |
| 3 |
|
CF América | 17 | 10 | 1 | 6 | 32:19 | 13 | 31 |
| 4 |
|
Club Tijuana | 17 | 9 | 4 | 4 | 25:19 | 6 | 31 |
| 5 |
|
Deportivo Guadalajara | 17 | 9 | 4 | 4 | 23:17 | 6 | 31 |
| 6 |
|
Deportivo Toluca | 17 | 8 | 5 | 4 | 25:19 | 6 | 29 |
| 7 |
|
UANL Tigres | 17 | 8 | 4 | 5 | 26:16 | 10 | 28 |
| 8 |
|
Santos Laguna | 17 | 8 | 4 | 5 | 23:25 | -2 | 28 |
| 9 |
|
Atlético San Luis | 17 | 7 | 4 | 6 | 33:27 | 6 | 25 |
| 10 |
|
Cruz Azul | 17 | 6 | 6 | 5 | 19:16 | 3 | 24 |
| 11 |
|
Club Necaxa | 17 | 7 | 2 | 8 | 25:25 | 0 | 23 |
| 12 |
|
Pumas UNAM | 17 | 6 | 4 | 7 | 24:21 | 3 | 22 |
| 13 |
|
Mazatlán FC | 17 | 6 | 2 | 9 | 20:28 | -8 | 20 |
| 14 |
|
CF Monterrey | 17 | 5 | 4 | 8 | 18:30 | -12 | 19 |
| 15 |
|
Atlas Guadalajara | 17 | 3 | 6 | 8 | 13:21 | -8 | 15 |
| 16 |
|
FC Juárez | 17 | 3 | 5 | 9 | 15:34 | -19 | 14 |
| 17 |
|
Puebla FC | 17 | 2 | 3 | 12 | 18:41 | -23 | 9 |
| 18 |
|
Gallos Blancos | 17 | 1 | 5 | 11 | 9:20 | -11 | 8 |
| Play-offs |
