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| 30.04.2022 | 17:00 | KF Shkëndija 79 | - | FK Rabotnički | 1:0 (0:0) | |
| 17:00 | FK Bregalnica Štip | - | KF Shkupi | 4:1 (1:1) | ||
| 01.05.2022 | 17:00 | Makedonija GP | - | Akademija Pandev | 1:0 (0:0) | |
| 17:00 | FK Renova | - | FC Struga | 1:1 (0:0) | ||
| 17:00 | FK Pelister | - | GFK Tikvesh | 1:1 (1:1) | ||
| 17:00 | FK Borec | - | FK Skopje | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 30 | 22 | 5 | 3 | 62:20 | 42 | 71 |
| 2 |
|
KF Shkëndija 79 | 30 | 16 | 11 | 3 | 46:20 | 26 | 59 |
| 3 |
|
Akademija Pandev | 30 | 17 | 7 | 6 | 49:26 | 23 | 58 |
| 4 |
|
Makedonija GP | 30 | 17 | 5 | 8 | 43:38 | 5 | 56 |
| 5 |
|
FK Bregalnica Štip | 30 | 11 | 9 | 10 | 43:42 | 1 | 42 |
| 6 |
|
FC Struga | 30 | 10 | 10 | 10 | 28:31 | -3 | 40 |
| 7 |
|
FK Renova | 30 | 9 | 12 | 9 | 34:28 | 6 | 39 |
| 8 |
|
FK Rabotnički | 30 | 11 | 4 | 15 | 24:31 | -7 | 37 |
| 9 |
|
GFK Tikvesh | 30 | 8 | 7 | 15 | 34:35 | -1 | 31 |
| 10 |
|
FK Skopje | 30 | 7 | 8 | 15 | 19:40 | -21 | 29 |
| 11 |
|
FK Borec | 30 | 5 | 6 | 19 | 22:57 | -35 | 21 |
| 12 |
|
FK Pelister | 30 | 1 | 8 | 21 | 11:47 | -36 | 11 |
| Champions League Kwali. | |
| Promotie en degradatie | |
| Degradatie |
