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| 02.11.2018 | 20:00 | FC Dordrecht | - | FC Volendam | 1:2 (0:2) | |
| 20:00 | SC Cambuur | - | Jong Ajax | 2:1 (1:0) | ||
| 20:00 | MVV Maastricht | - | Sparta Rotterdam | 0:2 (0:1) | ||
| 20:00 | TOP Oss | - | FC Eindhoven | 2:0 (2:0) | ||
| 20:00 | FC Twente | - | RKC Waalwijk | 3:1 (2:0) | ||
| 20:00 | Helmond Sport | - | Almere City FC | 1:2 (1:1) | ||
| 20:00 | Jong FC Utrecht | - | Roda JC Kerkrade | 1:2 (0:0) | ||
| 04.11.2018 | 14:30 | NEC Nijmegen | - | Jong AZ Alkmaar | 3:1 (0:1) | |
| 14:30 | Telstar | - | Go Ahead Eagles | 2:1 (0:0) | ||
| 05.11.2018 | 20:00 | Jong PSV | - | FC Den Bosch | 0:1 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sparta Rotterdam | 12 | 8 | 3 | 1 | 22:9 | 13 | 27 |
| 2 |
|
Go Ahead Eagles | 12 | 8 | 2 | 2 | 26:11 | 15 | 26 |
| 3 |
|
FC Twente | 12 | 8 | 2 | 2 | 26:12 | 14 | 26 |
| 4 |
|
FC Den Bosch | 12 | 8 | 1 | 3 | 20:13 | 7 | 25 |
| 5 |
|
Almere City FC | 12 | 7 | 2 | 3 | 22:14 | 8 | 23 |
| 6 |
|
TOP Oss | 12 | 6 | 3 | 3 | 18:9 | 9 | 21 |
| 7 |
|
NEC Nijmegen | 12 | 6 | 3 | 3 | 23:20 | 3 | 21 |
| 8 |
|
SC Cambuur | 12 | 6 | 2 | 4 | 17:15 | 2 | 20 |
| 9 |
|
Roda JC Kerkrade | 12 | 5 | 3 | 4 | 15:17 | -2 | 18 |
| 10 |
|
Jong Ajax | 12 | 5 | 1 | 6 | 19:18 | 1 | 16 |
| 11 |
|
Jong PSV | 12 | 4 | 4 | 4 | 21:23 | -2 | 16 |
| 12 |
|
MVV Maastricht | 12 | 4 | 4 | 4 | 11:15 | -4 | 16 |
| 13 |
|
Telstar | 12 | 5 | 0 | 7 | 14:19 | -5 | 15 |
| 14 |
|
FC Volendam | 12 | 3 | 5 | 4 | 13:16 | -3 | 14 |
| 15 |
|
RKC Waalwijk | 12 | 3 | 2 | 7 | 12:18 | -6 | 11 |
| 16 |
|
Jong AZ Alkmaar | 12 | 1 | 6 | 5 | 17:23 | -6 | 9 |
| 17 |
|
FC Eindhoven | 12 | 2 | 3 | 7 | 9:16 | -7 | 9 |
| 18 |
|
Helmond Sport | 12 | 0 | 6 | 6 | 13:22 | -9 | 6 |
| 19 |
|
FC Dordrecht | 12 | 1 | 3 | 8 | 13:24 | -11 | 6 |
| 20 |
|
Jong FC Utrecht | 12 | 1 | 3 | 8 | 12:29 | -17 | 6 |
| Promotie | |
| Play-offs | |
| Play-offs |
