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| 19.03.2021 | 20:00 | Almere City FC | - | FC Den Bosch | 2:0 (1:0) | |
| 20:00 | De Graafschap | - | SBV Excelsior | 1:1 (1:1) | ||
| 20:00 | TOP Oss | - | NEC Nijmegen | 2:1 (0:1) | ||
| 20:00 | FC Volendam | - | NAC Breda | 2:1 (1:0) | ||
| 20:00 | Go Ahead Eagles | - | FC Dordrecht | 5:1 (3:0) | ||
| 20:00 | Helmond Sport | - | Jong FC Utrecht | 2:1 (1:0) | ||
| 20:00 | Jong Ajax | - | MVV Maastricht | 4:3 (2:1) | ||
| 20:00 | Jong PSV | - | Jong AZ Alkmaar | 3:0 (2:0) | ||
| 20:00 | Telstar | - | Roda JC Kerkrade | 3:1 (1:1) | ||
| 22.03.2021 | 20:00 | SC Cambuur | - | FC Eindhoven | 3:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Cambuur | 29 | 22 | 4 | 3 | 80:22 | 58 | 70 |
| 2 |
|
De Graafschap | 29 | 20 | 4 | 5 | 58:37 | 21 | 64 |
| 3 |
|
Almere City FC | 29 | 19 | 5 | 5 | 65:38 | 27 | 62 |
| 4 |
|
NAC Breda | 29 | 18 | 5 | 6 | 58:29 | 29 | 59 |
| 5 |
|
Go Ahead Eagles | 29 | 17 | 6 | 6 | 46:19 | 27 | 57 |
| 6 |
|
NEC Nijmegen | 29 | 16 | 5 | 8 | 58:33 | 25 | 53 |
| 7 |
|
FC Volendam | 29 | 14 | 8 | 7 | 64:40 | 24 | 50 |
| 8 |
|
Roda JC Kerkrade | 29 | 12 | 9 | 8 | 55:44 | 11 | 45 |
| 9 |
|
SBV Excelsior | 29 | 11 | 4 | 14 | 54:50 | 4 | 37 |
| 10 |
|
Telstar | 29 | 10 | 7 | 12 | 48:44 | 4 | 37 |
| 11 |
|
Jong Ajax | 29 | 9 | 7 | 13 | 49:59 | -10 | 34 |
| 12 |
|
TOP Oss | 29 | 10 | 4 | 15 | 32:49 | -17 | 34 |
| 13 |
|
Helmond Sport | 29 | 8 | 9 | 12 | 40:52 | -12 | 33 |
| 14 |
|
MVV Maastricht | 29 | 9 | 5 | 15 | 35:58 | -23 | 32 |
| 15 |
|
FC Eindhoven | 29 | 7 | 8 | 14 | 38:52 | -14 | 29 |
| 16 |
|
Jong FC Utrecht | 29 | 9 | 1 | 19 | 39:56 | -17 | 28 |
| 17 |
|
Jong PSV | 29 | 7 | 6 | 16 | 40:57 | -17 | 27 |
| 18 |
|
Jong AZ Alkmaar | 29 | 6 | 5 | 18 | 40:78 | -38 | 23 |
| 19 |
|
FC Dordrecht | 29 | 6 | 3 | 20 | 28:75 | -47 | 21 |
| 20 |
|
FC Den Bosch | 29 | 4 | 7 | 18 | 33:68 | -35 | 19 |
| Promotie | |
| Play-offs |
