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| 08.04.2022 | 20:00 | ADO Den Haag | - | Helmond Sport | 2:1 (1:0) | |
| 20:00 | FC Den Bosch | - | FC Dordrecht | 3:0 (0:0) | ||
| 20:00 | FC Eindhoven | - | Almere City FC | 3:1 (2:1) | ||
| 20:00 | SBV Excelsior | - | Telstar | 1:4 (1:2) | ||
| 20:00 | FC Emmen | - | Jong AZ Alkmaar | 3:0 (1:0) | ||
| 20:00 | TOP Oss | - | Jong PSV | 2:0 (1:0) | ||
| 20:00 | FC Volendam | - | De Graafschap | 3:1 (1:1) | ||
| 20:00 | MVV Maastricht | - | Jong FC Utrecht | 2:4 (2:2) | ||
| 20:00 | NAC Breda | - | VVV-Venlo | 3:1 (2:0) | ||
| 20:00 | Roda JC Kerkrade | - | Jong Ajax | 2:2 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Emmen | 34 | 23 | 5 | 6 | 58:23 | 35 | 74 |
| 2 |
|
FC Volendam | 34 | 19 | 11 | 4 | 72:46 | 26 | 68 |
| 3 |
|
FC Eindhoven | 34 | 19 | 7 | 8 | 64:38 | 26 | 64 |
| 4 |
|
SBV Excelsior | 34 | 19 | 5 | 10 | 74:49 | 25 | 62 |
| 5 |
|
Roda JC Kerkrade | 34 | 16 | 12 | 6 | 68:41 | 27 | 60 |
| 6 |
|
ADO Den Haag | 34 | 20 | 6 | 8 | 73:49 | 24 | 60 |
| 7 |
|
Jong Ajax | 34 | 17 | 8 | 9 | 74:57 | 17 | 59 |
| 8 |
|
NAC Breda | 34 | 14 | 10 | 10 | 52:40 | 12 | 52 |
| 9 |
|
De Graafschap | 34 | 14 | 9 | 11 | 45:39 | 6 | 51 |
| 10 |
|
VVV-Venlo | 34 | 12 | 5 | 17 | 41:52 | -11 | 41 |
| 11 |
|
FC Den Bosch | 34 | 12 | 4 | 18 | 38:58 | -20 | 40 |
| 12 |
|
Jong PSV | 34 | 10 | 8 | 16 | 54:58 | -4 | 38 |
| 13 |
|
Almere City FC | 34 | 10 | 8 | 16 | 53:61 | -8 | 38 |
| 14 |
|
TOP Oss | 34 | 10 | 8 | 16 | 44:54 | -10 | 38 |
| 15 |
|
Jong AZ Alkmaar | 34 | 11 | 5 | 18 | 33:45 | -12 | 38 |
| 16 |
|
Telstar | 34 | 8 | 11 | 15 | 41:63 | -22 | 35 |
| 17 |
|
Jong FC Utrecht | 34 | 10 | 4 | 20 | 37:61 | -24 | 34 |
| 18 |
|
FC Dordrecht | 34 | 8 | 8 | 18 | 47:72 | -25 | 32 |
| 19 |
|
MVV Maastricht | 34 | 10 | 2 | 22 | 38:72 | -34 | 32 |
| 20 |
|
Helmond Sport | 34 | 7 | 6 | 21 | 34:62 | -28 | 24 |
| Promotie | |
| Play-offs | |
| Play-offs |
