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| 07.10.2022 | 20:00 | ADO Den Haag | - | FC Eindhoven | 1:0 (0:0) | |
| 20:00 | Jong Ajax | - | Helmond Sport | 0:1 (0:1) | ||
| 20:00 | Jong AZ Alkmaar | - | NAC Breda | 4:0 (1:0) | ||
| 20:00 | FC Dordrecht | - | PEC Zwolle | 3:0 (1:0) | ||
| 20:00 | Heracles Almelo | - | De Graafschap | 3:2 (1:1) | ||
| 20:00 | TOP Oss | - | MVV Maastricht | 0:1 (0:0) | ||
| 20:00 | Jong PSV | - | Telstar | 0:2 (0:0) | ||
| 20:00 | Roda JC Kerkrade | - | VVV-Venlo | 4:1 (1:1) | ||
| 20:00 | Jong FC Utrecht | - | Almere City FC | 0:2 (0:0) | ||
| 20:00 | Willem II | - | FC Den Bosch | 1:2 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Heracles Almelo | 10 | 8 | 1 | 1 | 27:12 | 15 | 25 |
| 2 |
|
PEC Zwolle | 10 | 6 | 2 | 2 | 24:14 | 10 | 20 |
| 3 |
|
MVV Maastricht | 10 | 6 | 2 | 2 | 20:17 | 3 | 20 |
| 4 |
|
FC Eindhoven | 10 | 5 | 4 | 1 | 18:9 | 9 | 19 |
| 5 |
|
Roda JC Kerkrade | 10 | 5 | 3 | 2 | 20:13 | 7 | 18 |
| 6 |
|
VVV-Venlo | 10 | 5 | 2 | 3 | 17:19 | -2 | 17 |
| 7 |
|
Jong AZ Alkmaar | 10 | 5 | 1 | 4 | 20:14 | 6 | 16 |
| 8 |
|
Almere City FC | 10 | 5 | 1 | 4 | 14:13 | 1 | 16 |
| 9 |
|
Willem II | 10 | 4 | 3 | 3 | 14:12 | 2 | 15 |
| 10 |
|
NAC Breda | 10 | 4 | 2 | 4 | 13:16 | -3 | 14 |
| 11 |
|
Jong Ajax | 10 | 3 | 3 | 4 | 16:15 | 1 | 12 |
| 12 |
|
Jong PSV | 10 | 3 | 3 | 4 | 12:17 | -5 | 12 |
| 13 |
|
Telstar | 10 | 3 | 3 | 4 | 10:16 | -6 | 12 |
| 14 |
|
FC Dordrecht | 10 | 3 | 2 | 5 | 12:14 | -2 | 11 |
| 15 |
|
ADO Den Haag | 10 | 3 | 2 | 5 | 12:17 | -5 | 11 |
| 16 |
|
TOP Oss | 10 | 3 | 1 | 6 | 12:16 | -4 | 10 |
| 17 |
|
FC Den Bosch | 10 | 3 | 0 | 7 | 13:19 | -6 | 9 |
| 18 |
|
Helmond Sport | 10 | 3 | 0 | 7 | 9:14 | -5 | 9 |
| 19 |
|
De Graafschap | 10 | 2 | 2 | 6 | 13:19 | -6 | 8 |
| 20 |
|
Jong FC Utrecht | 10 | 1 | 3 | 6 | 8:18 | -10 | 6 |
| Promotie | |
| Play-offs |
