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| 14.10.2022 | 20:00 | Almere City FC | - | Jong Ajax | 2:3 (1:2) | |
| 20:00 | FC Den Bosch | - | Jong AZ Alkmaar | 3:0 (1:0) | ||
| 20:00 | FC Eindhoven | - | TOP Oss | 2:1 (2:0) | ||
| 20:00 | De Graafschap | - | Jong FC Utrecht | 2:0 (2:0) | ||
| 20:00 | Helmond Sport | - | Willem II | 1:3 (0:2) | ||
| 20:00 | MVV Maastricht | - | Jong PSV | 1:1 (1:0) | ||
| 20:00 | NAC Breda | - | ADO Den Haag | 1:2 (1:2) | ||
| 20:00 | PEC Zwolle | - | Heracles Almelo | 3:2 (3:1) | ||
| 20:00 | Telstar | - | Roda JC Kerkrade | 2:1 (2:0) | ||
| 20:00 | VVV-Venlo | - | FC Dordrecht | 0:1 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Heracles Almelo | 11 | 8 | 1 | 2 | 29:15 | 14 | 25 |
| 2 |
|
PEC Zwolle | 11 | 7 | 2 | 2 | 27:16 | 11 | 23 |
| 3 |
|
FC Eindhoven | 11 | 6 | 4 | 1 | 20:10 | 10 | 22 |
| 4 |
|
MVV Maastricht | 11 | 6 | 3 | 2 | 21:18 | 3 | 21 |
| 5 |
|
Willem II | 11 | 5 | 3 | 3 | 17:13 | 4 | 18 |
| 6 |
|
Roda JC Kerkrade | 11 | 5 | 3 | 3 | 21:15 | 6 | 18 |
| 7 |
|
VVV-Venlo | 11 | 5 | 2 | 4 | 17:20 | -3 | 17 |
| 8 |
|
Jong AZ Alkmaar | 11 | 5 | 1 | 5 | 20:17 | 3 | 16 |
| 9 |
|
Almere City FC | 11 | 5 | 1 | 5 | 16:16 | 0 | 16 |
| 10 |
|
Jong Ajax | 11 | 4 | 3 | 4 | 19:17 | 2 | 15 |
| 11 |
|
Telstar | 11 | 4 | 3 | 4 | 12:17 | -5 | 15 |
| 12 |
|
FC Dordrecht | 11 | 4 | 2 | 5 | 13:14 | -1 | 14 |
| 13 |
|
ADO Den Haag | 11 | 4 | 2 | 5 | 14:18 | -4 | 14 |
|
NAC Breda | 11 | 4 | 2 | 5 | 14:18 | -4 | 14 | |
| 15 |
|
Jong PSV | 11 | 3 | 4 | 4 | 13:18 | -5 | 13 |
| 16 |
|
FC Den Bosch | 11 | 4 | 0 | 7 | 16:19 | -3 | 12 |
| 17 |
|
De Graafschap | 11 | 3 | 2 | 6 | 15:19 | -4 | 11 |
| 18 |
|
TOP Oss | 11 | 3 | 1 | 7 | 13:18 | -5 | 10 |
| 19 |
|
Helmond Sport | 11 | 3 | 0 | 8 | 10:17 | -7 | 9 |
| 20 |
|
Jong FC Utrecht | 11 | 1 | 3 | 7 | 8:20 | -12 | 6 |
| Promotie | |
| Play-offs |
