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| 04.11.2022 | 20:00 | ADO Den Haag | - | VVV-Venlo | 2:3 (1:1) | |
| 20:00 | FC Den Bosch | - | De Graafschap | 2:1 (1:1) | ||
| 20:00 | FC Dordrecht | - | Jong Ajax | 3:4 (2:1) | ||
| 20:00 | MVV Maastricht | - | Helmond Sport | 4:0 (2:0) | ||
| 20:00 | NAC Breda | - | Telstar | 1:1 (1:1) | ||
| 20:00 | TOP Oss | - | PEC Zwolle | 0:5 (0:2) | ||
| 20:00 | Willem II | - | Heracles Almelo | 1:2 (0:0) | ||
| 07.11.2022 | 20:00 | Jong AZ Alkmaar | - | Roda JC Kerkrade | 2:0 (2:0) | |
| 20:00 | Jong PSV | - | Almere City FC | 0:1 (0:0) | ||
| 20:00 | Jong FC Utrecht | - | FC Eindhoven | 0:1 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Heracles Almelo | 14 | 10 | 1 | 3 | 36:19 | 17 | 31 |
| 2 |
|
MVV Maastricht | 14 | 9 | 3 | 2 | 29:19 | 10 | 30 |
| 3 |
|
PEC Zwolle | 14 | 9 | 2 | 3 | 33:17 | 16 | 29 |
| 4 |
|
FC Eindhoven | 14 | 7 | 5 | 2 | 23:15 | 8 | 26 |
| 5 |
|
Jong AZ Alkmaar | 14 | 7 | 2 | 5 | 24:18 | 6 | 23 |
| 6 |
|
Almere City FC | 14 | 7 | 2 | 5 | 21:19 | 2 | 23 |
| 7 |
|
Willem II | 14 | 6 | 4 | 4 | 21:17 | 4 | 22 |
| 8 |
|
VVV-Venlo | 14 | 6 | 3 | 5 | 22:25 | -3 | 21 |
| 9 |
|
Roda JC Kerkrade | 14 | 6 | 3 | 5 | 25:21 | 4 | 21 |
| 10 |
|
Jong Ajax | 14 | 5 | 4 | 5 | 25:23 | 2 | 19 |
| 11 |
|
NAC Breda | 14 | 5 | 3 | 6 | 20:22 | -2 | 18 |
| 12 |
|
FC Den Bosch | 14 | 6 | 0 | 8 | 22:25 | -3 | 18 |
| 13 |
|
Telstar | 14 | 4 | 6 | 4 | 15:20 | -5 | 18 |
| 14 |
|
Jong PSV | 14 | 4 | 5 | 5 | 21:21 | 0 | 17 |
| 15 |
|
De Graafschap | 14 | 4 | 3 | 7 | 20:23 | -3 | 15 |
| 16 |
|
FC Dordrecht | 14 | 4 | 3 | 7 | 18:23 | -5 | 15 |
| 17 |
|
ADO Den Haag | 14 | 4 | 3 | 7 | 19:25 | -6 | 15 |
| 18 |
|
TOP Oss | 14 | 4 | 1 | 9 | 16:25 | -9 | 13 |
| 19 |
|
Helmond Sport | 14 | 4 | 0 | 10 | 12:28 | -16 | 12 |
| 20 |
|
Jong FC Utrecht | 14 | 1 | 3 | 10 | 9:26 | -17 | 6 |
| Promotie | |
| Play-offs |
