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| 14.04.2023 | 20:00 | PEC Zwolle | - | Telstar | 2:0 (1:0) | |
| 20:00 | MVV Maastricht | - | FC Dordrecht | 2:1 (1:0) | ||
| 20:00 | FC Den Bosch | - | Helmond Sport | 1:2 (1:1) | ||
| 20:00 | Heracles Almelo | - | Roda JC Kerkrade | 1:0 (1:0) | ||
| 20:00 | TOP Oss | - | De Graafschap | 3:3 (1:1) | ||
| 20:00 | VVV-Venlo | - | FC Eindhoven | 2:2 (0:1) | ||
| 16.04.2023 | 12:15 | ADO Den Haag | - | Almere City FC | 2:3 (2:1) | |
| 17.04.2023 | 20:00 | Jong Ajax | - | Jong PSV | 5:4 (3:2) | |
| 20:00 | Jong AZ Alkmaar | - | Jong FC Utrecht | 4:0 (2:0) | ||
| 25.04.2023 | 14:30 | NAC Breda | - | Willem II | 1:1 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
PEC Zwolle | 33 | 24 | 3 | 6 | 87:36 | 51 | 75 |
| 2 |
|
Heracles Almelo | 33 | 22 | 4 | 7 | 91:41 | 50 | 70 |
| 3 |
|
Almere City FC | 33 | 19 | 5 | 9 | 49:36 | 13 | 62 |
| 4 |
|
Willem II | 33 | 16 | 9 | 8 | 56:36 | 20 | 57 |
| 5 |
|
VVV-Venlo | 33 | 15 | 8 | 10 | 52:46 | 6 | 53 |
| 6 |
|
MVV Maastricht | 33 | 16 | 5 | 12 | 60:58 | 2 | 53 |
| 7 |
|
FC Eindhoven | 33 | 14 | 9 | 10 | 52:49 | 3 | 51 |
| 8 |
|
NAC Breda | 33 | 15 | 5 | 13 | 55:56 | -1 | 50 |
| 9 |
|
De Graafschap | 33 | 13 | 7 | 13 | 56:47 | 9 | 46 |
| 10 |
|
Jong AZ Alkmaar | 33 | 12 | 8 | 13 | 54:52 | 2 | 44 |
| 11 |
|
ADO Den Haag | 33 | 11 | 10 | 12 | 42:49 | -7 | 43 |
| 12 |
|
Telstar | 33 | 11 | 10 | 12 | 34:49 | -15 | 43 |
| 13 |
|
Roda JC Kerkrade | 33 | 12 | 6 | 15 | 43:47 | -4 | 42 |
| 14 |
|
Jong PSV | 33 | 11 | 8 | 14 | 55:56 | -1 | 41 |
| 15 |
|
Jong Ajax | 33 | 10 | 10 | 13 | 63:65 | -2 | 40 |
| 16 |
|
Helmond Sport | 33 | 10 | 8 | 15 | 33:50 | -17 | 38 |
| 17 |
|
TOP Oss | 33 | 9 | 5 | 19 | 41:64 | -23 | 32 |
| 18 |
|
FC Dordrecht | 33 | 8 | 6 | 19 | 35:57 | -22 | 30 |
| 19 |
|
FC Den Bosch | 33 | 9 | 3 | 21 | 43:79 | -36 | 30 |
| 20 |
|
Jong FC Utrecht | 33 | 6 | 5 | 22 | 31:59 | -28 | 23 |
| Promotie | |
| Play-offs |
