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| 26.08.2022 | 20:00 | Almere City FC | - | FC Den Bosch | 2:0 (1:0) | |
| 20:00 | FC Eindhoven | - | Jong AZ Alkmaar | 1:0 (1:0) | ||
| 20:00 | De Graafschap | - | FC Dordrecht | 1:1 (0:1) | ||
| 20:00 | TOP Oss | - | VVV-Venlo | 1:2 (1:1) | ||
| 20:00 | PEC Zwolle | - | Jong PSV | 4:2 (3:0) | ||
| 20:00 | Roda JC Kerkrade | - | NAC Breda | 1:3 (0:1) | ||
| 20:00 | Telstar | - | Helmond Sport | 2:1 (1:1) | ||
| 28.08.2022 | 12:15 | ADO Den Haag | - | Jong Ajax | 4:0 (2:0) | |
| 29.08.2022 | 20:00 | Heracles Almelo | - | MVV Maastricht | 2:2 (0:1) | |
| 20:00 | Jong FC Utrecht | - | Willem II | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
PEC Zwolle | 4 | 4 | 0 | 0 | 15:3 | 12 | 12 |
| 2 |
|
FC Eindhoven | 4 | 4 | 0 | 0 | 7:2 | 5 | 12 |
| 3 |
|
Heracles Almelo | 4 | 3 | 1 | 0 | 12:2 | 10 | 10 |
| 4 |
|
Jong AZ Alkmaar | 4 | 3 | 0 | 1 | 9:5 | 4 | 9 |
| 5 |
|
NAC Breda | 4 | 3 | 0 | 1 | 6:4 | 2 | 9 |
| 6 |
|
VVV-Venlo | 4 | 3 | 0 | 1 | 7:6 | 1 | 9 |
| 7 |
|
Roda JC Kerkrade | 4 | 3 | 0 | 1 | 7:3 | 4 | 9 |
| 8 |
|
MVV Maastricht | 4 | 2 | 1 | 1 | 9:7 | 2 | 7 |
| 9 |
|
Almere City FC | 4 | 2 | 0 | 2 | 7:6 | 1 | 6 |
| 10 |
|
Willem II | 4 | 1 | 2 | 1 | 4:4 | 0 | 5 |
| 11 |
|
Jong Ajax | 4 | 1 | 1 | 2 | 6:7 | -1 | 4 |
| 12 |
|
FC Dordrecht | 4 | 1 | 1 | 2 | 3:5 | -2 | 4 |
| 13 |
|
Jong PSV | 4 | 1 | 1 | 2 | 4:8 | -4 | 4 |
| 14 |
|
Telstar | 4 | 1 | 1 | 2 | 4:9 | -5 | 4 |
| 15 |
|
TOP Oss | 4 | 1 | 0 | 3 | 4:6 | -2 | 3 |
| 16 |
|
ADO Den Haag | 4 | 1 | 0 | 3 | 5:9 | -4 | 3 |
| 17 |
|
FC Den Bosch | 4 | 1 | 0 | 3 | 3:8 | -5 | 3 |
| 18 |
|
De Graafschap | 4 | 0 | 1 | 3 | 4:10 | -6 | 1 |
| 19 |
|
Jong FC Utrecht | 4 | 0 | 1 | 3 | 1:8 | -7 | 1 |
| 20 |
|
Helmond Sport | 4 | 0 | 0 | 4 | 2:7 | -5 | 0 |
| Promotie | |
| Play-offs |
