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| 19.12.2005 | 20:00 | AGOVV | - | FC Volendam | 0:1 (0:1) | |
| 20:00 | FC Eindhoven | - | HFC Haarlem | 2:4 (1:1) | ||
| 23.12.2005 | 20:00 | Go Ahead Eagles | - | FC Omniworld | 1:4 (0:0) | |
| 20:00 | Stormvogels Telstar | - | Helmond Sport | 2:1 (2:0) | ||
| 20:00 | VVV-Venlo | - | FC Emmen | 2:0 (2:0) | ||
| 20:00 | BV Veendam | - | MVV Maastricht | 3:3 (0:2) | ||
| 20:00 | SBV Excelsior | - | TOP Oss | 2:2 (2:1) | ||
| 20:00 | FC Den Bosch | - | FC Zwolle | 2:1 (2:0) | ||
| 20:00 | FC Dordrecht | - | De Graafschap | 0:2 (0:2) | ||
| 20:00 | Fortuna Sittard | - | SC Cambuur | 1:3 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VVV-Venlo | 24 | 15 | 6 | 3 | 38:12 | 26 | 51 |
| 2 |
|
SBV Excelsior | 24 | 15 | 5 | 4 | 47:15 | 32 | 50 |
| 3 |
|
FC Emmen | 24 | 13 | 3 | 8 | 46:30 | 16 | 42 |
| 4 |
|
FC Volendam | 24 | 12 | 6 | 6 | 36:26 | 10 | 42 |
| 5 |
|
FC Den Bosch | 24 | 11 | 8 | 5 | 45:35 | 10 | 41 |
| 6 |
|
Helmond Sport | 24 | 12 | 4 | 8 | 38:37 | 1 | 40 |
| 7 |
|
FC Zwolle | 24 | 11 | 6 | 7 | 42:30 | 12 | 39 |
| 8 |
|
De Graafschap | 24 | 10 | 6 | 8 | 34:28 | 6 | 36 |
| 9 |
|
MVV Maastricht | 24 | 9 | 8 | 7 | 35:31 | 4 | 35 |
| 10 |
|
BV Veendam | 24 | 9 | 6 | 9 | 34:33 | 1 | 33 |
| 11 |
|
FC Dordrecht | 24 | 8 | 8 | 8 | 28:27 | 1 | 32 |
| 12 |
|
HFC Haarlem | 24 | 9 | 5 | 10 | 34:43 | -9 | 32 |
| 13 |
|
AGOVV | 24 | 9 | 3 | 12 | 41:42 | -1 | 30 |
| 14 |
|
TOP Oss | 24 | 7 | 8 | 9 | 30:39 | -9 | 29 |
| 15 |
|
Stormvogels Telstar | 24 | 6 | 8 | 10 | 20:32 | -12 | 26 |
| 16 |
|
Go Ahead Eagles | 24 | 6 | 7 | 11 | 29:42 | -13 | 25 |
| 17 |
|
SC Cambuur | 24 | 5 | 9 | 10 | 24:35 | -11 | 21 |
| 18 |
|
FC Eindhoven | 24 | 5 | 5 | 14 | 33:42 | -9 | 20 |
| 19 |
|
FC Omniworld | 24 | 5 | 5 | 14 | 31:55 | -24 | 20 |
| 20 |
|
Fortuna Sittard | 24 | 1 | 8 | 15 | 22:53 | -31 | 11 |
| Promotie |
