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| 03.02.2006 | 20:00 | SC Cambuur | - | FC Omniworld | 1:0 (1:0) | |
| 20:00 | SBV Excelsior | - | De Graafschap | 4:1 (1:1) | ||
| 20:00 | Go Ahead Eagles | - | MVV Maastricht | 1:1 (1:1) | ||
| 05.02.2006 | 14:30 | Stormvogels Telstar | - | HFC Haarlem | 1:4 (0:2) | |
| 06.02.2006 | 20:00 | Fortuna Sittard | - | TOP Oss | 2:1 (1:1) | |
| 13.02.2006 | 20:00 | FC Den Bosch | - | FC Volendam | 1:0 (0:0) | |
| 20:00 | AGOVV | - | BV Veendam | 1:1 (0:0) | ||
| 20:00 | FC Eindhoven | - | FC Dordrecht | 1:3 (1:0) | ||
| 20:00 | VVV-Venlo | - | FC Zwolle | 1:0 (0:0) | ||
| 20:00 | FC Emmen | - | Helmond Sport | 1:1 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 28 | 17 | 6 | 5 | 57:18 | 39 | 57 |
| 2 |
|
VVV-Venlo | 28 | 16 | 7 | 5 | 40:15 | 25 | 55 |
| 3 |
|
FC Emmen | 28 | 15 | 5 | 8 | 53:33 | 20 | 50 |
| 4 |
|
FC Volendam | 28 | 14 | 7 | 7 | 41:30 | 11 | 49 |
| 5 |
|
FC Den Bosch | 28 | 13 | 9 | 6 | 50:38 | 12 | 48 |
| 6 |
|
Helmond Sport | 28 | 13 | 6 | 9 | 44:43 | 1 | 45 |
| 7 |
|
De Graafschap | 28 | 12 | 6 | 10 | 41:36 | 5 | 42 |
| 8 |
|
HFC Haarlem | 28 | 12 | 6 | 10 | 46:46 | 0 | 42 |
| 9 |
|
FC Zwolle | 28 | 11 | 8 | 9 | 45:39 | 6 | 41 |
| 10 |
|
MVV Maastricht | 28 | 10 | 10 | 8 | 39:35 | 4 | 40 |
| 11 |
|
BV Veendam | 28 | 10 | 7 | 11 | 41:42 | -1 | 37 |
| 12 |
|
AGOVV | 28 | 11 | 4 | 13 | 47:49 | -2 | 37 |
| 13 |
|
FC Dordrecht | 28 | 9 | 9 | 10 | 34:33 | 1 | 36 |
| 14 |
|
TOP Oss | 28 | 8 | 10 | 10 | 34:43 | -9 | 34 |
| 15 |
|
SC Cambuur | 28 | 7 | 10 | 11 | 30:40 | -10 | 28 |
| 16 |
|
Stormvogels Telstar | 28 | 6 | 10 | 12 | 25:42 | -17 | 28 |
| 17 |
|
Go Ahead Eagles | 28 | 6 | 10 | 12 | 32:50 | -18 | 28 |
| 18 |
|
FC Omniworld | 28 | 7 | 6 | 15 | 36:58 | -22 | 27 |
| 19 |
|
FC Eindhoven | 28 | 6 | 5 | 17 | 36:49 | -13 | 23 |
| 20 |
|
Fortuna Sittard | 28 | 2 | 9 | 17 | 28:60 | -32 | 15 |
| Promotie |
