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| 07.11.2008 | 20:00 | MVV Maastricht | - | Fortuna Sittard | 0:2 (0:0) | |
| 20:00 | VVV-Venlo | - | AGOVV | 3:1 (2:0) | ||
| 20:00 | RBC Roosendaal | - | RKC Waalwijk | 2:2 (2:0) | ||
| 20:00 | TOP Oss | - | Go Ahead Eagles | 0:2 (0:0) | ||
| 20:00 | SBV Excelsior | - | BV Veendam | 4:1 (1:1) | ||
| 20:00 | FC Zwolle | - | Helmond Sport | 0:1 (0:0) | ||
| 20:00 | FC Emmen | - | HFC Haarlem | 2:0 (1:0) | ||
| 20:00 | Telstar | - | FC Omniworld | 3:1 (2:1) | ||
| 20:00 | FC Dordrecht | - | FC Den Bosch | 0:1 (0:1) | ||
| 20:00 | FC Eindhoven | - | SC Cambuur | 3:3 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VVV-Venlo | 15 | 12 | 2 | 1 | 38:12 | 26 | 38 |
| 2 |
|
SBV Excelsior | 15 | 10 | 1 | 4 | 28:15 | 13 | 31 |
| 3 |
|
RKC Waalwijk | 15 | 7 | 8 | 0 | 25:12 | 13 | 29 |
| 4 |
|
Helmond Sport | 15 | 7 | 5 | 3 | 25:18 | 7 | 26 |
| 5 |
|
SC Cambuur | 15 | 8 | 2 | 5 | 30:24 | 6 | 26 |
| 6 |
|
FC Den Bosch | 15 | 7 | 4 | 4 | 27:18 | 9 | 25 |
| 7 |
|
MVV Maastricht | 15 | 6 | 5 | 4 | 21:16 | 5 | 23 |
| 8 |
|
FC Zwolle | 15 | 5 | 5 | 5 | 21:19 | 2 | 20 |
| 9 |
|
HFC Haarlem | 15 | 6 | 2 | 7 | 23:28 | -5 | 20 |
| 10 |
|
Go Ahead Eagles | 15 | 5 | 5 | 5 | 13:20 | -7 | 20 |
| 11 |
|
AGOVV | 15 | 5 | 3 | 7 | 23:29 | -6 | 18 |
| 12 |
|
BV Veendam | 15 | 5 | 5 | 5 | 20:25 | -5 | 17 |
| 13 |
|
RBC Roosendaal | 15 | 4 | 4 | 7 | 19:22 | -3 | 16 |
| 14 |
|
TOP Oss | 15 | 4 | 4 | 7 | 18:24 | -6 | 16 |
| 15 |
|
Fortuna Sittard | 15 | 3 | 6 | 6 | 15:24 | -9 | 15 |
| 16 |
|
FC Emmen | 15 | 4 | 3 | 8 | 18:32 | -14 | 15 |
| 17 |
|
FC Eindhoven | 15 | 3 | 8 | 4 | 28:31 | -3 | 14 |
| 18 |
|
Telstar | 15 | 3 | 5 | 7 | 21:26 | -5 | 14 |
| 19 |
|
FC Dordrecht | 15 | 3 | 3 | 9 | 13:17 | -4 | 12 |
| 20 |
|
FC Omniworld | 15 | 2 | 2 | 11 | 15:29 | -14 | 8 |
| Promotie | |
| Play-offs | |
| Play-offs | |
| Play-offs | |
| Play-offs |
