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| 22.04.2011 | 20:00 | SC Cambuur | - | Fortuna Sittard | 2:1 (0:1) | |
| 20:00 | Almere City FC | - | Helmond Sport | 4:0 (2:0) | ||
| 20:00 | FC Eindhoven | - | BV Veendam | 3:1 (1:0) | ||
| 20:00 | RBC Roosendaal | - | AGOVV | 2:2 (0:2) | ||
| 20:00 | FC Volendam | - | Sparta Rotterdam | 3:1 (1:0) | ||
| 20:00 | FC Dordrecht | - | Go Ahead Eagles | 1:1 (0:1) | ||
| 20:00 | MVV Maastricht | - | Telstar | 2:1 (1:1) | ||
| 20:00 | FC Zwolle | - | RKC Waalwijk | 0:3 (0:1) | ||
| 20:00 | FC Emmen | - | FC Den Bosch | 0:3 (0:2) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Zwolle | 32 | 20 | 8 | 4 | 66:24 | 42 | 67 |
| 2 |
|
RKC Waalwijk | 32 | 20 | 7 | 5 | 76:39 | 37 | 67 |
| 3 |
|
Helmond Sport | 32 | 16 | 7 | 9 | 56:42 | 14 | 55 |
| 4 |
|
BV Veendam | 32 | 15 | 10 | 7 | 52:42 | 10 | 51 |
| 5 |
|
SC Cambuur | 32 | 14 | 8 | 10 | 58:48 | 10 | 47 |
| 6 |
|
FC Volendam | 32 | 13 | 8 | 11 | 51:48 | 3 | 47 |
| 7 |
|
Go Ahead Eagles | 32 | 12 | 10 | 10 | 55:41 | 14 | 46 |
| 8 |
|
FC Den Bosch | 32 | 10 | 13 | 9 | 55:47 | 8 | 43 |
| 9 |
|
MVV Maastricht | 32 | 14 | 8 | 10 | 43:44 | -1 | 42 |
| 10 |
|
FC Eindhoven | 32 | 10 | 9 | 13 | 39:44 | -5 | 39 |
| 11 |
|
FC Dordrecht | 32 | 11 | 9 | 12 | 48:52 | -4 | 38 |
| 12 |
|
Sparta Rotterdam | 32 | 10 | 7 | 15 | 67:65 | 2 | 37 |
| 13 |
|
FC Emmen | 32 | 8 | 10 | 14 | 45:60 | -15 | 34 |
| 14 |
|
Telstar | 32 | 8 | 9 | 15 | 41:48 | -7 | 33 |
| 15 |
|
AGOVV | 32 | 11 | 7 | 14 | 53:74 | -21 | 31 |
| 16 |
|
Fortuna Sittard | 32 | 7 | 6 | 19 | 41:68 | -27 | 25 |
| 17 |
|
Almere City FC | 32 | 8 | 6 | 18 | 45:83 | -38 | 24 |
| 18 |
|
RBC Roosendaal | 32 | 6 | 8 | 18 | 35:57 | -22 | 23 |
| Promotie | |
| Play-offs | |
| Play-offs | |
| Degradatie |
