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| 03.10.2021 | 15:00 | SG Finnentrop/Bamenohl | - | SG Wattenscheid 09 | 0:2 (0:0) | |
| 15:00 | Preußen Münster II | - | TuS Haltern | 3:1 (2:0) | ||
| 15:00 | Holzwickeder SC | - | TSG Sprockhövel | 0:5 (0:2) | ||
| 15:00 | SC Paderborn 07 II | - | FC Gütersloh | 1:1 (0:1) | ||
| 15:00 | 1. FC Kaan-Marienborn | - | SV Schermbeck | 1:0 (0:0) | ||
| 15:00 | Viktoria Clarholz | - | TuS Ennepetal | 0:1 (0:0) | ||
| 15:00 | RSV Meinerzhagen | - | SpVgg Vreden | 0:1 (0:0) | ||
| 15:15 | Westfalia Herne | - | Sportfreunde Siegen | 0:2 (0:2) | ||
| 18:00 | Westfalia Rhynern | - | Hammer SpVg | 5:2 (2:0) | ||
| 27.10.2021 | 19:30 | ASC 09 Dortmund | - | FCE Rheine | 0:1 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SG Wattenscheid 09 | 6 | 5 | 0 | 1 | 14:8 | 6 | 15 |
| 2 |
|
FCE Rheine | 6 | 5 | 0 | 1 | 8:4 | 4 | 15 |
| 3 |
|
TSG Sprockhövel | 6 | 4 | 1 | 1 | 19:6 | 13 | 13 |
| 4 |
|
1. FC Kaan-Marienborn | 5 | 4 | 1 | 0 | 16:4 | 12 | 13 |
|
SC Paderborn 07 II | 6 | 4 | 1 | 1 | 16:4 | 12 | 13 | |
| 6 |
|
ASC 09 Dortmund | 6 | 3 | 1 | 2 | 13:10 | 3 | 10 |
| 7 |
|
Preußen Münster II | 6 | 3 | 1 | 2 | 12:11 | 1 | 10 |
| 8 |
|
TuS Ennepetal | 6 | 3 | 1 | 2 | 13:13 | 0 | 10 |
| 9 |
|
Westfalia Rhynern | 6 | 3 | 0 | 3 | 16:13 | 3 | 9 |
| 10 |
|
FC Gütersloh | 5 | 2 | 2 | 1 | 7:5 | 2 | 8 |
| 11 |
|
Sportfreunde Siegen | 6 | 2 | 2 | 2 | 9:9 | 0 | 8 |
| 12 |
|
SV Schermbeck | 6 | 2 | 1 | 3 | 14:11 | 3 | 7 |
| 13 |
|
TuS Haltern | 5 | 1 | 3 | 1 | 5:5 | 0 | 6 |
| 14 |
|
Hammer SpVg | 6 | 2 | 0 | 4 | 13:14 | -1 | 6 |
| 15 |
|
TuS Erndtebrück | 5 | 1 | 3 | 1 | 8:9 | -1 | 6 |
| 16 |
|
Holzwickeder SC | 6 | 2 | 0 | 4 | 8:18 | -10 | 6 |
| 17 |
|
SpVgg Vreden | 6 | 1 | 2 | 3 | 5:13 | -8 | 5 |
| 18 |
|
RSV Meinerzhagen | 6 | 1 | 0 | 5 | 7:15 | -8 | 3 |
| 19 |
|
Viktoria Clarholz | 5 | 0 | 2 | 3 | 7:12 | -5 | 2 |
| 20 |
|
SG Finnentrop/Bamenohl | 5 | 0 | 2 | 3 | 5:16 | -11 | 2 |
| 21 |
|
Westfalia Herne | 6 | 0 | 1 | 5 | 2:17 | -15 | 1 |
| Play-offs | |
| Promotie en degradatie |
