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| U | Alianza | - | Atlético Chiriquí | 1:0 (1:0) | ||
| R | Atlético Chiriquí | - | Alianza | 1:1 (0:0) | ||
| U: 15.05.2022 03:00 | R: 22.05.2022 03:00 | Winnaars: Alianza | ||||
| U | Tauro FC | - | Sporting San Miguelito | 1:2 (0:1) | ||
| R | Sporting San Miguelito | - | Tauro FC | 0:0 (0:0) | ||
| U: 16.05.2022 01:30 | R: 23.05.2022 01:00 | Winnaars: Sporting San Miguelito | ||||
