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| 26.04.2022 | 23:00 | Deportivo del Este | - | Alianza | 1:2 (1:2) | |
| 27.04.2022 | 01:00 | San Francisco FC | - | Atlético Chiriquí | 2:2 (1:0) | |
| 03:00 | Sporting San Miguelito | - | Árabe Unido | 1:0 (1:0) | ||
| 28.04.2022 | 03:00 | Plaza Amador | - | Tauro FC | 1:0 (1:0) | |
| 03:00 | Herrera FC | - | Independiente de La Chorrera | 4:0 (3:0) | ||
| 03:00 | Veraguas United | - | UD Universitario | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Alianza | 14 | 8 | 4 | 2 | 15:6 | 9 | 28 |
| 2 |
|
Sporting San Miguelito | 14 | 7 | 6 | 1 | 20:11 | 9 | 27 |
| 3 |
|
Tauro FC | 14 | 7 | 3 | 4 | 17:10 | 7 | 24 |
| 4 |
|
Plaza Amador | 14 | 5 | 7 | 2 | 24:18 | 6 | 22 |
| 5 |
|
Deportivo del Este | 14 | 2 | 7 | 5 | 14:19 | -5 | 13 |
| 6 |
|
Árabe Unido | 14 | 1 | 7 | 6 | 4:10 | -6 | 10 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Chiriquí | 14 | 7 | 3 | 4 | 19:19 | 0 | 24 |
| 2 |
|
Herrera FC | 14 | 4 | 8 | 2 | 19:12 | 7 | 20 |
| 3 |
|
Independiente de La Chorrera | 14 | 6 | 2 | 6 | 15:19 | -4 | 20 |
| 4 |
|
San Francisco FC | 14 | 3 | 5 | 6 | 14:13 | 1 | 14 |
| 5 |
|
Veraguas United | 14 | 2 | 6 | 6 | 12:22 | -10 | 12 |
| 6 |
|
UD Universitario | 14 | 2 | 2 | 10 | 8:22 | -14 | 8 |
| Play-offs | |
| Play-offs | |
| Play-offs | |
| Play-offs |
