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| 26.03.2022 | 02:00 | San Francisco FC | - | Sporting San Miguelito | 0:1 (0:1) | |
| 02:00 | Alianza | - | UD Universitario | 2:0 (0:0) | ||
| 02:00 | Veraguas United | - | Deportivo del Este | 1:1 (1:0) | ||
| 22:00 | Tauro FC | - | Independiente de La Chorrera | 1:2 (0:0) | ||
| 27.03.2022 | 00:00 | Plaza Amador | - | Herrera FC | 1:1 (0:1) | |
| 03:00 | Atlético Chiriquí | - | Árabe Unido | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Alianza | 9 | 5 | 3 | 1 | 8:2 | 6 | 18 |
| 2 |
|
Sporting San Miguelito | 9 | 4 | 5 | 0 | 12:7 | 5 | 17 |
| 3 |
|
Tauro FC | 9 | 3 | 3 | 3 | 10:8 | 2 | 12 |
| 4 |
|
Plaza Amador | 9 | 2 | 5 | 2 | 12:13 | -1 | 11 |
| 5 |
|
Deportivo del Este | 9 | 1 | 6 | 2 | 9:10 | -1 | 9 |
| 6 |
|
Árabe Unido | 9 | 0 | 5 | 4 | 2:6 | -4 | 5 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Chiriquí | 9 | 6 | 1 | 2 | 13:10 | 3 | 19 |
| 2 |
|
Independiente de La Chorrera | 9 | 5 | 2 | 2 | 10:6 | 4 | 17 |
| 3 |
|
Herrera FC | 9 | 2 | 6 | 1 | 9:7 | 2 | 12 |
| 4 |
|
UD Universitario | 9 | 2 | 2 | 5 | 6:12 | -6 | 8 |
| 5 |
|
Veraguas United | 9 | 1 | 4 | 4 | 8:14 | -6 | 7 |
| 6 |
|
San Francisco FC | 9 | 1 | 2 | 6 | 4:8 | -4 | 5 |
| Play-offs | |
| Play-offs | |
| Play-offs | |
| Play-offs |
