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| U | Sporting CP | - | FC Porto | 1:2 (0:0) | ||
| R | FC Porto | - | Sporting CP | 1:0 (0:0) | ||
| U: 02.03.2022 21:45 | R: 21.04.2022 21:15 | Winnaars: FC Porto | ||||
| U | CD Tondela | - | CD Mafra | 3:0 (1:0) | ||
| R | CD Mafra | - | CD Tondela | 1:1 (1:0) | ||
| U: 03.03.2022 21:15 | R: 20.04.2022 21:15 | Winnaars: CD Tondela | ||||
