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| 28.08.2021 | 14:00 | Rot Weiss Ahlen | - | Fortuna Düsseldorf II | 1:1 (0:0) | |
| 14:00 | SV Rödinghausen | - | VfB Homberg | 0:1 (0:0) | ||
| 14:00 | Sportfreunde Lotte | - | FC Schalke 04 II | 2:0 (1:0) | ||
| 14:00 | Bor. Mönchengladbach II | - | SV Lippstadt 08 | 4:2 (3:0) | ||
| 14:00 | Alemannia Aachen | - | Rot-Weiß Oberhausen | 1:3 (0:1) | ||
| 14:00 | 1. FC Köln II | - | KFC Uerdingen 05 | 8:2 (4:1) | ||
| 14:00 | SC Wiedenbrück | - | Bonner SC | 3:1 (1:0) | ||
| 14:00 | SV 19 Straelen | - | Wuppertaler SV | 1:4 (1:1) | ||
| 29.08.2021 | 14:00 | FC Wegberg-Beeck | - | Preußen Münster | 0:4 (0:1) | |
| 14:00 | Rot-Weiss Essen | - | Fortuna Köln | 2:1 (0:1) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Preußen Münster | 4 | 4 | 0 | 0 | 10:2 | 8 | 12 |
| 2 |
|
Fortuna Düsseldorf II | 4 | 3 | 1 | 0 | 8:4 | 4 | 10 |
| 3 |
|
1. FC Köln II | 4 | 3 | 0 | 1 | 13:5 | 8 | 9 |
| 4 |
|
Rot-Weiß Oberhausen | 4 | 3 | 0 | 1 | 10:2 | 8 | 9 |
| 5 |
|
SV 19 Straelen | 4 | 3 | 0 | 1 | 11:8 | 3 | 9 |
| 6 |
|
SC Wiedenbrück | 4 | 3 | 0 | 1 | 7:4 | 3 | 9 |
| 7 |
|
Rot-Weiss Essen | 4 | 3 | 0 | 1 | 7:5 | 2 | 9 |
| 8 |
|
Fortuna Köln | 4 | 2 | 1 | 1 | 8:4 | 4 | 7 |
| 9 |
|
Wuppertaler SV | 4 | 2 | 1 | 1 | 6:2 | 4 | 7 |
| 10 |
|
Bor. Mönchengladbach II | 4 | 2 | 0 | 2 | 7:5 | 2 | 6 |
| 11 |
|
Sportfreunde Lotte | 4 | 2 | 0 | 2 | 5:4 | 1 | 6 |
| 12 |
|
SV Lippstadt 08 | 4 | 2 | 0 | 2 | 6:7 | -1 | 6 |
| 13 |
|
FC Schalke 04 II | 4 | 1 | 1 | 2 | 3:5 | -2 | 4 |
| 14 |
|
VfB Homberg | 4 | 1 | 1 | 2 | 2:5 | -3 | 4 |
| 15 |
|
Rot Weiss Ahlen | 4 | 0 | 3 | 1 | 4:5 | -1 | 3 |
| 16 |
|
Bonner SC | 4 | 1 | 0 | 3 | 5:10 | -5 | 3 |
| 17 |
|
Alemannia Aachen | 4 | 0 | 1 | 3 | 3:8 | -5 | 1 |
| 18 |
|
FC Wegberg-Beeck | 4 | 0 | 1 | 3 | 2:9 | -7 | 1 |
| 19 |
|
SV Rödinghausen | 4 | 0 | 0 | 4 | 2:10 | -8 | 0 |
| 20 |
|
KFC Uerdingen 05 | 4 | 0 | 0 | 4 | 5:20 | -15 | 0 |
| Promotie | |
| Degradatie |
