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| 10.12.2022 | 14:00 | Bor. Mönchengladbach II | - | 1. FC Düren | 5:0 (0:0) | |
| 14:00 | SV 19 Straelen | - | Rot-Weiß Oberhausen | 0:4 (0:1) | ||
| 14:00 | SG Wattenscheid 09 | - | Rot Weiss Ahlen | 4:3 (0:2) | ||
| 14:00 | SC Wiedenbrück | - | Wuppertaler SV | 1:1 (1:1) | ||
| 15:30 | 1. FC Köln II | - | 1. FC Kaan-Marienborn | 0:1 (0:1) | ||
| 27.01.2023 | 19:30 | Alemannia Aachen | - | Fortuna Düsseldorf II | 1:0 (1:0) | |
| 22.02.2023 | 19:00 | SV Lippstadt 08 | - | FC Schalke 04 II | 0:0 (0:0) | |
| 25.03.2023 | 14:00 | SV Rödinghausen | - | Fortuna Köln | 1:0 (0:0) | |
| 14:00 | 1. FC Bocholt | - | Preußen Münster | 1:2 (1:2) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Preußen Münster | 20 | 15 | 2 | 3 | 52:21 | 31 | 47 |
| 2 |
|
Bor. Mönchengladbach II | 20 | 10 | 6 | 4 | 37:22 | 15 | 36 |
| 3 |
|
Wuppertaler SV | 20 | 10 | 6 | 4 | 38:24 | 14 | 36 |
| 4 |
|
Alemannia Aachen | 20 | 10 | 6 | 4 | 31:22 | 9 | 36 |
| 5 |
|
1. FC Kaan-Marienborn | 20 | 10 | 4 | 6 | 29:27 | 2 | 34 |
| 6 |
|
Rot-Weiß Oberhausen | 20 | 9 | 5 | 6 | 36:32 | 4 | 32 |
| 7 |
|
FC Schalke 04 II | 20 | 8 | 7 | 5 | 40:24 | 16 | 31 |
| 8 |
|
SV Rödinghausen | 20 | 9 | 4 | 7 | 33:19 | 14 | 31 |
| 9 |
|
SV Lippstadt 08 | 20 | 9 | 4 | 7 | 33:33 | 0 | 31 |
| 10 |
|
Fortuna Köln | 20 | 8 | 5 | 7 | 23:27 | -4 | 29 |
| 11 |
|
SC Wiedenbrück | 20 | 6 | 6 | 8 | 29:24 | 5 | 24 |
| 12 |
|
Fortuna Düsseldorf II | 20 | 7 | 2 | 11 | 32:40 | -8 | 23 |
| 13 |
|
1. FC Düren | 20 | 7 | 2 | 11 | 23:39 | -16 | 23 |
| 14 |
|
Rot Weiss Ahlen | 20 | 5 | 5 | 10 | 34:42 | -8 | 20 |
| 15 |
|
1. FC Bocholt | 20 | 5 | 5 | 10 | 28:43 | -15 | 20 |
| 16 |
|
1. FC Köln II | 20 | 5 | 5 | 10 | 27:42 | -15 | 20 |
| 17 |
|
SG Wattenscheid 09 | 20 | 5 | 3 | 12 | 31:54 | -23 | 18 |
| 18 |
|
SV 19 Straelen | 20 | 2 | 3 | 15 | 12:33 | -21 | 9 |
| Promotie | |
| Degradatie | |
| Degradatie |
