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| 06.03.2021 | 12:00 | CSKA Moskou | - | Akhmat Grozny | 2:0 (1:0) | |
| 14:30 | Rotor Volgograd | - | FK Khimki | 0:0 (0:0) | ||
| 17:00 | FK Rostov | - | FK Sochi | 0:0 (0:0) | ||
| 07.03.2021 | 12:00 | FK Ural | - | FK Ufa | 0:0 (0:0) | |
| 14:30 | Dinamo Moskou | - | FK Tambov | 2:0 (1:0) | ||
| 17:00 | Spartak Moskou | - | FK Krasnodar | 6:1 (2:0) | ||
| 08.03.2021 | 12:00 | Arsenal Tula | - | Lokomotiv Moskou | 0:3 (0:0) | |
| 14:30 | Rubin Kazan | - | Zenit St. Petersburg | 2:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit St. Petersburg | 21 | 12 | 6 | 3 | 46:19 | 27 | 42 |
| 2 |
|
CSKA Moskou | 21 | 12 | 4 | 5 | 37:19 | 18 | 40 |
| 3 |
|
Spartak Moskou | 21 | 11 | 5 | 5 | 39:24 | 15 | 38 |
| 4 |
|
FK Sochi | 21 | 10 | 7 | 4 | 32:22 | 10 | 37 |
| 5 |
|
Dinamo Moskou | 21 | 11 | 3 | 7 | 28:22 | 6 | 36 |
| 6 |
|
FK Rostov | 21 | 10 | 4 | 7 | 26:22 | 4 | 34 |
| 7 |
|
Lokomotiv Moskou | 21 | 10 | 4 | 7 | 26:25 | 1 | 34 |
| 8 |
|
Rubin Kazan | 21 | 10 | 4 | 7 | 28:26 | 2 | 34 |
| 9 |
|
FK Krasnodar | 21 | 9 | 4 | 8 | 38:27 | 11 | 31 |
| 10 |
|
FK Khimki | 21 | 8 | 5 | 8 | 26:31 | -5 | 29 |
| 11 |
|
Akhmat Grozny | 21 | 7 | 5 | 9 | 20:25 | -5 | 26 |
| 12 |
|
FK Ural | 21 | 4 | 11 | 6 | 18:25 | -7 | 23 |
| 13 |
|
Rotor Volgograd | 21 | 4 | 6 | 11 | 12:31 | -19 | 18 |
| 14 |
|
FK Ufa | 21 | 3 | 5 | 13 | 15:33 | -18 | 14 |
| 15 |
|
Arsenal Tula | 21 | 3 | 5 | 13 | 17:37 | -20 | 14 |
| 16 |
|
FK Tambov | 21 | 3 | 4 | 14 | 14:34 | -20 | 13 |
| Champions League | |
| Champions League Kwali. | |
| Europa League Kwali. | |
| Promotie en degradatie | |
| Degradatie |
