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| 06.05.2022 | 17:00 | Krylia Sovetov | - | Dinamo Moskou | 5:2 (1:1) | |
| 07.05.2022 | 13:00 | FK Ural | - | Spartak Moskou | 1:3 (0:3) | |
| 15:30 | FK Nizhny Novgorod | - | Akhmat Grozny | 0:1 (0:0) | ||
| 15:30 | Zenit St. Petersburg | - | FK Khimki | 1:0 (1:0) | ||
| 18:00 | CSKA Moskou | - | FK Sochi | 0:1 (0:1) | ||
| 08.05.2022 | 13:00 | FK Ufa | - | FK Rostov | 0:0 (0:0) | |
| 15:30 | Arsenal Tula | - | FK Krasnodar | 1:1 (1:0) | ||
| 18:00 | Lokomotiv Moskou | - | Rubin Kazan | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit St. Petersburg | 28 | 19 | 7 | 2 | 65:26 | 39 | 64 |
| 2 |
|
FK Sochi | 28 | 16 | 4 | 8 | 49:29 | 20 | 52 |
| 3 |
|
Dinamo Moskou | 28 | 16 | 4 | 8 | 49:33 | 16 | 52 |
| 4 |
|
CSKA Moskou | 28 | 14 | 5 | 9 | 38:28 | 10 | 47 |
| 5 |
|
FK Krasnodar | 28 | 13 | 7 | 8 | 40:29 | 11 | 46 |
| 6 |
|
Lokomotiv Moskou | 28 | 12 | 8 | 8 | 39:36 | 3 | 44 |
| 7 |
|
Krylia Sovetov | 28 | 12 | 5 | 11 | 39:34 | 5 | 41 |
| 8 |
|
Akhmat Grozny | 28 | 12 | 2 | 14 | 34:37 | -3 | 38 |
| 9 |
|
Spartak Moskou | 28 | 10 | 7 | 11 | 35:38 | -3 | 37 |
| 10 |
|
FK Rostov | 28 | 9 | 8 | 11 | 45:46 | -1 | 35 |
| 11 |
|
FK Khimki | 28 | 6 | 11 | 11 | 31:44 | -13 | 29 |
| 12 |
|
Rubin Kazan | 28 | 8 | 5 | 15 | 33:51 | -18 | 29 |
| 13 |
|
FK Nizhny Novgorod | 28 | 7 | 8 | 13 | 25:39 | -14 | 29 |
| 14 |
|
FK Ural | 28 | 6 | 9 | 13 | 22:34 | -12 | 27 |
| 15 |
|
FK Ufa | 28 | 4 | 12 | 12 | 25:38 | -13 | 24 |
| 16 |
|
Arsenal Tula | 28 | 5 | 8 | 15 | 28:55 | -27 | 23 |
| Promotie en degradatie | |
| Degradatie |
