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| 23.04.2022 | 18:00 | Zlaté Moravce | - | AS Trenčín | 0:2 (0:2) | |
| 18:00 | Tatran Liptovský Mikuláš | - | FK Pohronie | 1:0 (0:0) | ||
| 18:00 | MFK Zemplín Michalovce | - | FK Senica | 1:0 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AS Trenčín | 29 | 11 | 8 | 10 | 48:39 | 9 | 41 |
| 2 |
|
Tatran Liptovský Mikuláš | 29 | 10 | 7 | 12 | 38:49 | -11 | 37 |
| 3 |
|
MFK Zemplín Michalovce | 29 | 11 | 3 | 15 | 27:37 | -10 | 36 |
| 4 |
|
FK Senica | 29 | 9 | 6 | 14 | 29:47 | -18 | 33 |
| 5 |
|
Zlaté Moravce | 29 | 6 | 8 | 15 | 30:47 | -17 | 26 |
| 6 |
|
FK Pohronie | 29 | 2 | 6 | 21 | 22:56 | -34 | 12 |
| Play-offs | |
| Degradatie |
