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| 30.04.2022 | 18:00 | FK Pohronie | - | MFK Zemplín Michalovce | 1:2 (0:1) | |
| 18:00 | AS Trenčín | - | Tatran Liptovský Mikuláš | 5:2 (2:1) | ||
| 18:00 | FK Senica | - | Zlaté Moravce | 0:0 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AS Trenčín | 30 | 12 | 8 | 10 | 53:41 | 12 | 44 |
| 2 |
|
MFK Zemplín Michalovce | 30 | 12 | 3 | 15 | 29:38 | -9 | 39 |
| 3 |
|
Tatran Liptovský Mikuláš | 30 | 10 | 7 | 13 | 40:54 | -14 | 37 |
| 4 |
|
FK Senica | 30 | 9 | 7 | 14 | 29:47 | -18 | 34 |
| 5 |
|
Zlaté Moravce | 30 | 6 | 9 | 15 | 30:47 | -17 | 27 |
| 6 |
|
FK Pohronie | 30 | 2 | 6 | 22 | 23:58 | -35 | 12 |
| Play-offs | |
| Degradatie |
