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| 05.11.2021 | 18:00 | Tuzlaspor | - | Denizlispor | 3:0 (0:0) | |
| 06.11.2021 | 10:30 | İstanbulspor AŞ | - | Menemen Belediyespor | 3:2 (2:0) | |
| 11:30 | Boluspor | - | Bandırmaspor | 0:0 (0:0) | ||
| 14:00 | Samsunspor | - | Manisa FK | 1:0 (0:0) | ||
| 17:00 | Altınordu FK | - | Eyüpspor | 1:2 (1:1) | ||
| 17:00 | MKE Ankaragücü | - | Ümraniyespor | 3:0 (1:0) | ||
| 07.11.2021 | 11:30 | Keçiörengücü | - | Gençlerbirliği | 2:0 (0:0) | |
| 14:00 | Balıkesirspor | - | Adanaspor | 1:2 (0:1) | ||
| 17:00 | Kocaelispor | - | Bursaspor | 2:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 12 | 8 | 3 | 1 | 22:8 | 14 | 27 |
| 2 |
|
Ümraniyespor | 12 | 8 | 3 | 1 | 21:7 | 14 | 27 |
| 3 |
|
Eyüpspor | 12 | 8 | 2 | 2 | 21:13 | 8 | 26 |
| 4 |
|
Bandırmaspor | 12 | 7 | 1 | 4 | 20:10 | 10 | 22 |
| 5 |
|
BB Erzurumspor | 11 | 7 | 1 | 3 | 17:11 | 6 | 22 |
| 6 |
|
Kocaelispor | 11 | 6 | 2 | 3 | 12:11 | 1 | 20 |
| 7 |
|
Tuzlaspor | 11 | 5 | 2 | 4 | 13:10 | 3 | 17 |
| 8 |
|
İstanbulspor AŞ | 11 | 5 | 1 | 5 | 17:15 | 2 | 16 |
| 9 |
|
Samsunspor | 11 | 4 | 3 | 4 | 15:16 | -1 | 15 |
| 10 |
|
Adanaspor | 12 | 4 | 3 | 5 | 15:17 | -2 | 15 |
| 11 |
|
Bursaspor | 11 | 4 | 2 | 5 | 15:15 | 0 | 14 |
| 12 |
|
Gençlerbirliği | 11 | 4 | 2 | 5 | 12:18 | -6 | 14 |
| 13 |
|
Boluspor | 11 | 3 | 4 | 4 | 11:11 | 0 | 13 |
| 14 |
|
Denizlispor | 11 | 3 | 2 | 6 | 10:16 | -6 | 11 |
| 15 |
|
Menemen Belediyespor | 11 | 3 | 2 | 6 | 14:21 | -7 | 11 |
| 16 |
|
Keçiörengücü | 11 | 3 | 1 | 7 | 10:16 | -6 | 10 |
| 17 |
|
Manisa FK | 12 | 3 | 1 | 8 | 14:21 | -7 | 10 |
| 18 |
|
Altınordu FK | 12 | 3 | 1 | 8 | 13:25 | -12 | 10 |
| 19 |
|
Balıkesirspor | 11 | 2 | 0 | 9 | 8:19 | -11 | 6 |
| Promotie | |
| Play-offs | |
| Degradatie |
