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| 25.02.2022 | 18:00 | Adana Demirspor | - | Antalyaspor | 0:0 (0:0) | |
| 18:00 | Trabzonspor | - | Kayserispor | 3:2 (0:2) | ||
| 26.02.2022 | 14:00 | İstanbul Başakşehir | - | Fatih Karagümrük SK | 1:2 (1:2) | |
| 17:00 | Sivasspor | - | Beşiktaş | 2:3 (1:2) | ||
| 27.02.2022 | 11:30 | Altay Izmir | - | Gaziantep FK | 3:2 (2:2) | |
| 11:30 | Giresunspor | - | Göztepe | 3:1 (1:0) | ||
| 14:00 | Alanyaspor | - | Konyaspor | 5:1 (4:1) | ||
| 14:00 | Hatayspor | - | Yeni Malatyaspor | 5:2 (3:0) | ||
| 17:00 | Galatasaray | - | Çaykur Rizespor | 4:2 (1:1) | ||
| 28.02.2022 | 18:00 | Kasımpaşa SK | - | Fenerbahçe | 1:2 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 27 | 20 | 6 | 1 | 51:20 | 31 | 66 |
| 2 |
|
Konyaspor | 27 | 14 | 7 | 6 | 42:29 | 13 | 49 |
| 3 |
|
İstanbul Başakşehir | 27 | 14 | 4 | 9 | 39:26 | 13 | 46 |
| 4 |
|
Fenerbahçe | 27 | 13 | 7 | 7 | 42:31 | 11 | 46 |
| 5 |
|
Adana Demirspor | 27 | 12 | 9 | 6 | 42:27 | 15 | 45 |
| 6 |
|
Beşiktaş | 27 | 12 | 8 | 7 | 40:34 | 6 | 44 |
| 7 |
|
Alanyaspor | 27 | 12 | 7 | 8 | 49:41 | 8 | 43 |
| 8 |
|
Hatayspor | 27 | 13 | 3 | 11 | 42:43 | -1 | 42 |
| 9 |
|
Fatih Karagümrük SK | 27 | 11 | 6 | 10 | 33:40 | -7 | 39 |
| 10 |
|
Kayserispor | 27 | 10 | 8 | 9 | 40:40 | 0 | 38 |
| 11 |
|
Gaziantep FK | 27 | 10 | 6 | 11 | 34:37 | -3 | 36 |
| 12 |
|
Galatasaray | 27 | 9 | 8 | 10 | 37:39 | -2 | 35 |
| 13 |
|
Sivasspor | 27 | 8 | 10 | 9 | 35:34 | 1 | 34 |
| 14 |
|
Antalyaspor | 27 | 8 | 8 | 11 | 28:35 | -7 | 32 |
| 15 |
|
Kasımpaşa SK | 27 | 7 | 8 | 12 | 37:40 | -3 | 29 |
| 16 |
|
Giresunspor | 27 | 8 | 5 | 14 | 27:31 | -4 | 29 |
| 17 |
|
Göztepe | 27 | 7 | 6 | 14 | 32:41 | -9 | 27 |
| 18 |
|
Altay Izmir | 27 | 7 | 4 | 16 | 29:41 | -12 | 25 |
| 19 |
|
Çaykur Rizespor | 27 | 6 | 5 | 16 | 24:48 | -24 | 23 |
| 20 |
|
Yeni Malatyaspor | 27 | 4 | 5 | 18 | 22:48 | -26 | 17 |
| Champions League | |
| Champions League Kwali. | |
| Degradatie |
