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| 17.09.2021 | 19:00 | Altay Izmir | - | Göztepe | 2:1 (0:1) | |
| 19:00 | Yeni Malatyaspor | - | Fatih Karagümrük SK | 3:4 (3:2) | ||
| 18.09.2021 | 12:30 | Sivasspor | - | Gaziantep FK | 1:1 (1:0) | |
| 15:00 | Kasımpaşa SK | - | Trabzonspor | 0:1 (0:0) | ||
| 18:00 | Adana Demirspor | - | Çaykur Rizespor | 3:1 (2:0) | ||
| 18:00 | Antalyaspor | - | Beşiktaş | 2:3 (2:0) | ||
| 19.09.2021 | 12:30 | Giresunspor | - | Konyaspor | 0:0 (0:0) | |
| 15:00 | Galatasaray | - | Alanyaspor | 0:1 (0:0) | ||
| 18:00 | Hatayspor | - | Kayserispor | 2:1 (0:1) | ||
| 18:00 | İstanbul Başakşehir | - | Fenerbahçe | 2:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Beşiktaş | 5 | 4 | 1 | 0 | 10:2 | 8 | 13 |
| 2 |
|
Trabzonspor | 5 | 4 | 1 | 0 | 11:4 | 7 | 13 |
| 3 |
|
Konyaspor | 5 | 3 | 2 | 0 | 7:3 | 4 | 11 |
| 4 |
|
Hatayspor | 5 | 3 | 1 | 1 | 11:4 | 7 | 10 |
| 5 |
|
Fatih Karagümrük SK | 5 | 3 | 1 | 1 | 11:6 | 5 | 10 |
| 6 |
|
Fenerbahçe | 5 | 3 | 1 | 1 | 6:3 | 3 | 10 |
| 7 |
|
Altay Izmir | 5 | 3 | 0 | 2 | 10:7 | 3 | 9 |
| 8 |
|
Alanyaspor | 5 | 3 | 0 | 2 | 4:9 | -5 | 9 |
| 9 |
|
Galatasaray | 5 | 2 | 2 | 1 | 8:6 | 2 | 8 |
| 10 |
|
Kayserispor | 5 | 2 | 1 | 2 | 5:6 | -1 | 7 |
| 11 |
|
Yeni Malatyaspor | 5 | 2 | 0 | 3 | 7:12 | -5 | 6 |
| 12 |
|
Göztepe | 5 | 1 | 2 | 2 | 6:7 | -1 | 5 |
| 13 |
|
Gaziantep FK | 5 | 1 | 2 | 2 | 5:6 | -1 | 5 |
|
Kasımpaşa SK | 5 | 1 | 2 | 2 | 5:6 | -1 | 5 | |
| 15 |
|
Adana Demirspor | 5 | 1 | 2 | 2 | 5:8 | -3 | 5 |
| 16 |
|
Antalyaspor | 5 | 1 | 1 | 3 | 6:10 | -4 | 4 |
| 17 |
|
Sivasspor | 5 | 0 | 3 | 2 | 5:7 | -2 | 3 |
| 18 |
|
İstanbul Başakşehir | 5 | 1 | 0 | 4 | 4:6 | -2 | 3 |
| 19 |
|
Giresunspor | 5 | 0 | 1 | 4 | 0:6 | -6 | 1 |
| 20 |
|
Çaykur Rizespor | 5 | 0 | 1 | 4 | 3:11 | -8 | 1 |
| Champions League | |
| Champions League Kwali. | |
| Degradatie |
