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| 21.09.2021 | 16:00 | Çaykur Rizespor | - | Altay Izmir | 1:2 (0:1) | |
| 16:00 | Fatih Karagümrük SK | - | Antalyaspor | 0:0 (0:0) | ||
| 19:00 | Beşiktaş | - | Adana Demirspor | 3:3 (2:0) | ||
| 19:00 | Yeni Malatyaspor | - | Sivasspor | 0:1 (0:0) | ||
| 22.09.2021 | 16:00 | Gaziantep FK | - | İstanbul Başakşehir | 1:0 (1:0) | |
| 19:00 | Göztepe | - | Hatayspor | 0:2 (0:1) | ||
| 19:00 | Kayserispor | - | Galatasaray | 3:0 (2:0) | ||
| 23.09.2021 | 16:00 | Konyaspor | - | Trabzonspor | 2:2 (1:1) | |
| 19:00 | Alanyaspor | - | Kasımpaşa SK | 2:0 (0:0) | ||
| 19:00 | Fenerbahçe | - | Giresunspor | 2:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Beşiktaş | 6 | 4 | 2 | 0 | 13:5 | 8 | 14 |
| 2 |
|
Trabzonspor | 6 | 4 | 2 | 0 | 13:6 | 7 | 14 |
| 3 |
|
Hatayspor | 6 | 4 | 1 | 1 | 13:4 | 9 | 13 |
| 4 |
|
Fenerbahçe | 6 | 4 | 1 | 1 | 8:4 | 4 | 13 |
| 5 |
|
Altay Izmir | 6 | 4 | 0 | 2 | 12:8 | 4 | 12 |
| 6 |
|
Konyaspor | 6 | 3 | 3 | 0 | 9:5 | 4 | 12 |
| 7 |
|
Alanyaspor | 6 | 4 | 0 | 2 | 6:9 | -3 | 12 |
| 8 |
|
Fatih Karagümrük SK | 6 | 3 | 2 | 1 | 11:6 | 5 | 11 |
| 9 |
|
Kayserispor | 6 | 3 | 1 | 2 | 8:6 | 2 | 10 |
| 10 |
|
Gaziantep FK | 6 | 2 | 2 | 2 | 6:6 | 0 | 8 |
| 11 |
|
Galatasaray | 6 | 2 | 2 | 2 | 8:9 | -1 | 8 |
| 12 |
|
Sivasspor | 6 | 1 | 3 | 2 | 6:7 | -1 | 6 |
| 13 |
|
Adana Demirspor | 6 | 1 | 3 | 2 | 8:11 | -3 | 6 |
| 14 |
|
Yeni Malatyaspor | 6 | 2 | 0 | 4 | 7:13 | -6 | 6 |
| 15 |
|
Göztepe | 6 | 1 | 2 | 3 | 6:9 | -3 | 5 |
| 16 |
|
Kasımpaşa SK | 6 | 1 | 2 | 3 | 5:8 | -3 | 5 |
| 17 |
|
Antalyaspor | 6 | 1 | 2 | 3 | 6:10 | -4 | 5 |
| 18 |
|
İstanbul Başakşehir | 6 | 1 | 0 | 5 | 4:7 | -3 | 3 |
| 19 |
|
Giresunspor | 6 | 0 | 1 | 5 | 1:8 | -7 | 1 |
| 20 |
|
Çaykur Rizespor | 6 | 0 | 1 | 5 | 4:13 | -9 | 1 |
| Champions League | |
| Champions League Kwali. | |
| Degradatie |
