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| 01.10.2021 | 19:00 | Antalyaspor | - | Adana Demirspor | 1:2 (0:1) | |
| 19:00 | Fatih Karagümrük SK | - | İstanbul Başakşehir | 3:1 (3:0) | ||
| 02.10.2021 | 12:30 | Konyaspor | - | Alanyaspor | 1:1 (0:0) | |
| 15:00 | Göztepe | - | Giresunspor | 0:1 (0:0) | ||
| 15:00 | Kayserispor | - | Trabzonspor | 1:2 (1:1) | ||
| 18:00 | Beşiktaş | - | Sivasspor | 2:1 (1:0) | ||
| 03.10.2021 | 12:30 | Yeni Malatyaspor | - | Hatayspor | 0:2 (0:1) | |
| 15:00 | Fenerbahçe | - | Kasımpaşa SK | 2:1 (2:0) | ||
| 15:00 | Gaziantep FK | - | Altay Izmir | 4:1 (0:0) | ||
| 18:00 | Çaykur Rizespor | - | Galatasaray | 2:3 (2:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Fenerbahçe | 8 | 6 | 1 | 1 | 12:6 | 6 | 19 |
| 2 |
|
Trabzonspor | 8 | 5 | 3 | 0 | 16:8 | 8 | 18 |
| 3 |
|
Beşiktaş | 8 | 5 | 2 | 1 | 16:8 | 8 | 17 |
| 4 |
|
Hatayspor | 8 | 5 | 1 | 2 | 16:6 | 10 | 16 |
| 5 |
|
Altay Izmir | 8 | 5 | 0 | 3 | 15:13 | 2 | 15 |
| 6 |
|
Konyaspor | 8 | 3 | 5 | 0 | 12:8 | 4 | 14 |
| 7 |
|
Fatih Karagümrük SK | 8 | 4 | 2 | 2 | 14:11 | 3 | 14 |
| 8 |
|
Galatasaray | 8 | 4 | 2 | 2 | 13:12 | 1 | 14 |
| 9 |
|
Alanyaspor | 8 | 4 | 2 | 2 | 8:11 | -3 | 14 |
| 10 |
|
Adana Demirspor | 8 | 3 | 3 | 2 | 14:12 | 2 | 12 |
| 11 |
|
Kayserispor | 8 | 3 | 2 | 3 | 10:9 | 1 | 11 |
| 12 |
|
Gaziantep FK | 8 | 3 | 2 | 3 | 10:11 | -1 | 11 |
| 13 |
|
Sivasspor | 8 | 2 | 3 | 3 | 11:9 | 2 | 9 |
| 14 |
|
Antalyaspor | 8 | 2 | 2 | 4 | 8:12 | -4 | 8 |
| 15 |
|
İstanbul Başakşehir | 8 | 2 | 0 | 6 | 8:10 | -2 | 6 |
| 16 |
|
Kasımpaşa SK | 8 | 1 | 3 | 4 | 8:12 | -4 | 6 |
| 17 |
|
Yeni Malatyaspor | 8 | 2 | 0 | 6 | 7:16 | -9 | 6 |
| 18 |
|
Göztepe | 8 | 1 | 2 | 5 | 7:12 | -5 | 5 |
| 19 |
|
Giresunspor | 8 | 1 | 2 | 5 | 3:9 | -6 | 5 |
| 20 |
|
Çaykur Rizespor | 8 | 0 | 1 | 7 | 6:19 | -13 | 1 |
| Champions League | |
| Champions League Kwali. | |
| Degradatie |
