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| U | Karsspor | - | Gençlerbirliği | 1:2 (0:0) | ||
| R | Gençlerbirliği | - | Karsspor | 2:1 (0:0) | ||
| U: 28.11.2017 11:00 | R: 13.12.2017 11:30 | Winnaars: Gençlerbirliği | ||||
| U | Beşiktaş | - | Manisaspor | 9:0 (4:0) | ||
| R | Manisaspor | - | Beşiktaş | 1:1 (0:1) | ||
| U: 28.11.2017 12:30 | R: 12.12.2017 19:00 | Winnaars: Beşiktaş | ||||
| U | Ankara Demirspor | - | Akhisar Belediyespor | 0:3 (0:2) | ||
| R | Akhisar Belediyespor | - | Ankara Demirspor | 1:1 (1:1) | ||
| U: 28.11.2017 12:45 | R: 13.12.2017 12:30 | Winnaars: Akhisar Belediyespor | ||||
| U | Osmanlıspor FK | - | Yeni Malatyaspor | 3:1 (1:0) | ||
| R | Yeni Malatyaspor | - | Osmanlıspor FK | 1:1 (1:1) | ||
| U: 28.11.2017 16:00 | R: 13.12.2017 15:00 | Winnaars: Osmanlıspor FK | ||||
| U | Galatasaray | - | Sivas Belediyespor | 5:1 (1:0) | ||
| R | Sivas Belediyespor | - | Galatasaray | 2:1 (1:1) | ||
| U: 28.11.2017 18:30 | R: 12.12.2017 17:30 | Winnaars: Galatasaray | ||||
| U | Batman Petrolspor | - | Atiker Konyaspor | 0:3 (0:1) | ||
| R | Atiker Konyaspor | - | Batman Petrolspor | 2:0 (0:0) | ||
| U: 29.11.2017 11:00 | R: 14.12.2017 14:00 | Winnaars: Atiker Konyaspor | ||||
| U | Kasımpaşa SK | - | Boluspor | 1:3 (0:1) | ||
| R | Boluspor | - | Kasımpaşa SK | 4:1 (2:1) | ||
| U: 29.11.2017 12:30 | R: 12.12.2017 14:30 | Winnaars: Boluspor | ||||
| U | Sivasspor | - | Bucaspor | 2:1 (0:0) | ||
| R | Bucaspor | - | Sivasspor | 1:0 (1:0) | ||
| U: 29.11.2017 14:00 | R: 13.12.2017 14:30 | Winnaars: Bucaspor | ||||
| U | Karabükspor | - | İstanbulspor AŞ | 2:1 (2:0) | ||
| R | İstanbulspor AŞ | - | Karabükspor | 1:0 (1:0) | ||
| U: 29.11.2017 14:30 | R: 14.12.2017 12:00 | Winnaars: İstanbulspor AŞ | ||||
| U | Adanaspor | - | Bursaspor | 0:2 (0:2) | ||
| R | Bursaspor | - | Adanaspor | 2:0 (2:0) | ||
| U: 29.11.2017 16:45 | R: 12.12.2017 13:30 | Winnaars: Bursaspor | ||||
| U | Fenerbahçe | - | Adana Demirspor | 6:0 (3:0) | ||
| R | Adana Demirspor | - | Fenerbahçe | 1:4 (1:2) | ||
| U: 29.11.2017 18:30 | R: 13.12.2017 18:30 | Winnaars: Fenerbahçe | ||||
| U | Orhangazispor | - | Antalyaspor | 0:3 (0:0) | ||
| R | Antalyaspor | - | Orhangazispor | 2:3 (1:1) | ||
| U: 30.11.2017 11:30 | R: 12.12.2017 11:30 | Winnaars: Antalyaspor | ||||
| U | Giresunspor | - | Alanyaspor | 4:2 (3:2) | ||
| R | Alanyaspor | - | Giresunspor | 2:2 (1:1) | ||
| U: 30.11.2017 13:30 | R: 13.12.2017 16:45 | Winnaars: Giresunspor | ||||
| U | Kahramanmaraşspor | - | İstanbul Başakşehir | 1:3 (1:2) | ||
| R | İstanbul Başakşehir | - | Kahramanmaraşspor | 1:0 (0:0) | ||
| U: 30.11.2017 14:30 | R: 14.12.2017 18:00 | Winnaars: İstanbul Başakşehir | ||||
| U | BB Erzurumspor | - | Trabzonspor | 0:4 (0:2) | ||
| R | Trabzonspor | - | BB Erzurumspor | 5:1 (0:0) | ||
| U: 30.11.2017 15:30 | R: 12.12.2017 15:30 | Winnaars: Trabzonspor | ||||
| U | Kayserispor | - | Eyüpspor | 3:2 (1:0) | ||
| R | Eyüpspor | - | Kayserispor | 0:2 (0:0) | ||
| U: 30.11.2017 18:30 | R: 14.12.2017 11:30 | Winnaars: Kayserispor | ||||
