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| 02.04.2021 | 18:00 | SK Dnipro-1 | - | FK Lviv | 5:1 (1:0) | |
| 03.04.2021 | 13:00 | FK Mariupol | - | Inhulets Petrove | 4:3 (1:0) | |
| 16:00 | Rukh Lviv | - | Zorya Lugansk | 0:2 (0:1) | ||
| 18:30 | Desna Chernigov | - | Olimpik Donetsk | 2:0 (1:0) | ||
| 04.04.2021 | 13:00 | FC Mynai | - | Kolos Kovalivka | 0:0 (0:0) | |
| 16:00 | Vorskla Poltava | - | Shakhtar Donetsk | 0:2 (0:1) | ||
| 18:30 | FK Oleksandriya | - | Dinamo Kiev | 1:2 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Dinamo Kiev | 20 | 15 | 4 | 1 | 43:14 | 29 | 49 |
| 2 |
|
Shakhtar Donetsk | 20 | 12 | 6 | 2 | 44:15 | 29 | 42 |
| 3 |
|
Zorya Lugansk | 20 | 10 | 5 | 5 | 34:16 | 18 | 35 |
| 4 |
|
Desna Chernigov | 20 | 9 | 6 | 5 | 29:20 | 9 | 33 |
| 5 |
|
Vorskla Poltava | 20 | 8 | 7 | 5 | 27:17 | 10 | 31 |
| 6 |
|
Kolos Kovalivka | 20 | 7 | 9 | 4 | 26:19 | 7 | 30 |
| 7 |
|
FK Oleksandriya | 20 | 7 | 5 | 8 | 27:24 | 3 | 26 |
| 8 |
|
SK Dnipro-1 | 20 | 7 | 4 | 9 | 30:31 | -1 | 25 |
| 9 |
|
FK Mariupol | 20 | 5 | 6 | 9 | 21:31 | -10 | 21 |
| 10 |
|
Olimpik Donetsk | 20 | 6 | 2 | 12 | 24:36 | -12 | 20 |
| 11 |
|
Inhulets Petrove | 20 | 3 | 10 | 7 | 20:31 | -11 | 19 |
| 12 |
|
FK Lviv | 20 | 5 | 4 | 11 | 17:45 | -28 | 19 |
| 13 |
|
FC Mynai | 20 | 3 | 6 | 11 | 12:34 | -22 | 15 |
| 14 |
|
Rukh Lviv | 20 | 2 | 8 | 10 | 16:37 | -21 | 14 |
| Champions League | |
| Champions League Kwali. | |
| Degradatie |
