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| 10.09.2021 | 18:30 | FK Oleksandriya | - | Inhulets Petrove | 1:0 (0:0) | |
| 11.09.2021 | 13:00 | Rukh Lviv | - | Zorya Lugansk | 1:1 (1:0) | |
| 16:00 | Metalist 1925 Kharkiv | - | Dinamo Kiev | 0:2 (0:0) | ||
| 18:30 | Shakhtar Donetsk | - | SK Dnipro-1 | 2:0 (1:0) | ||
| 12.09.2021 | 13:00 | FC Mynai | - | Chernomorets Odessa | 2:2 (1:0) | |
| 16:00 | Kolos Kovalivka | - | FK Mariupol | 1:3 (0:2) | ||
| 18:30 | Vorskla Poltava | - | Desna Chernigov | 2:2 (2:2) | ||
| 13.09.2021 | 18:30 | NK Veres | - | FK Lviv | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Dinamo Kiev | 7 | 6 | 1 | 0 | 22:2 | 20 | 19 |
| 2 |
|
Shakhtar Donetsk | 7 | 5 | 1 | 1 | 14:4 | 10 | 16 |
| 3 |
|
FK Oleksandriya | 7 | 4 | 2 | 1 | 8:5 | 3 | 14 |
| 4 |
|
SK Dnipro-1 | 7 | 4 | 1 | 2 | 12:8 | 4 | 13 |
| 5 |
|
Desna Chernigov | 7 | 4 | 1 | 2 | 11:12 | -1 | 13 |
| 6 |
|
Vorskla Poltava | 7 | 3 | 3 | 1 | 13:7 | 6 | 12 |
| 7 |
|
Zorya Lugansk | 7 | 3 | 2 | 2 | 13:9 | 4 | 11 |
| 8 |
|
NK Veres | 7 | 3 | 2 | 2 | 8:7 | 1 | 11 |
| 9 |
|
Rukh Lviv | 7 | 2 | 2 | 3 | 6:9 | -3 | 8 |
| 10 |
|
FC Mynai | 7 | 1 | 4 | 2 | 6:8 | -2 | 7 |
| 11 |
|
Inhulets Petrove | 7 | 2 | 1 | 4 | 8:12 | -4 | 7 |
| 12 |
|
Metalist 1925 Kharkiv | 7 | 2 | 0 | 5 | 6:12 | -6 | 6 |
| 13 |
|
Kolos Kovalivka | 7 | 1 | 3 | 3 | 4:13 | -9 | 6 |
| 14 |
|
Chernomorets Odessa | 7 | 1 | 2 | 4 | 9:18 | -9 | 5 |
| 15 |
|
FK Mariupol | 7 | 1 | 1 | 5 | 11:16 | -5 | 4 |
| 16 |
|
FK Lviv | 7 | 0 | 2 | 5 | 4:13 | -9 | 2 |
| Champions League Kwali. | |
| Promotie en degradatie | |
| Degradatie |
