8. Ronde | 12.09.2021 | Sportivo Luqueño | - | River Plate | 0:2 | ||||
9. Ronde | 18.09.2021 | River Plate | - | Libertad | 0:1 | ||||
10. Ronde | 27.09.2021 | River Plate | - | Club Olimpia | 1:2 | ||||
11. Ronde | 03.10.2021 | River Plate | - | Guaireña FC | 1:1 | ||||
12. Ronde | 19.10.2021 | Cerro Porteño | - | River Plate | 2:0 |