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| 30.08.2021 | 17:00 | RFC Seraing II | - | KVC Westerlo II | 1:0 | |
| 19:30 | SK Beveren II | - | Lierse Kempenzonen II | 6:0 | ||
| 20:00 | KAS Eupen II | - | RWDM Brussels FC II | 2:2 | ||
| 20:00 | K Beerschot VA II | - | SK Deinze II | 1:0 | ||
| 20:00 | Excelsior Virton II | - | Lommel SK II | 3:2 | ||
| 20:00 | KV Oostende II | - | Union St. Gilloise II | 1:1 | ||
| 20:30 | Royal Excel Mouscron II | - | KV Kortrijk II | 2:0 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SK Beveren II | 2 | 2 | 0 | 0 | 7:0 | 7 | 6 |
| 2 |
|
RFC Seraing II | 2 | 2 | 0 | 0 | 3:0 | 3 | 6 |
| 3 |
|
KV Oostende II | 2 | 1 | 1 | 0 | 9:1 | 8 | 4 |
| 4 |
|
KAS Eupen II | 2 | 1 | 1 | 0 | 5:3 | 2 | 4 |
| 5 |
|
Union St. Gilloise II | 2 | 1 | 1 | 0 | 3:2 | 1 | 4 |
| 6 |
|
Royal Excel Mouscron II | 2 | 1 | 0 | 1 | 2:1 | 1 | 3 |
| 7 |
|
SK Deinze II | 2 | 1 | 0 | 1 | 1:1 | 0 | 3 |
| 8 |
|
K Beerschot VA II | 2 | 1 | 0 | 1 | 1:2 | -1 | 3 |
| 9 |
|
Lierse Kempenzonen II | 2 | 1 | 0 | 1 | 1:6 | -5 | 3 |
| 10 |
|
Excelsior Virton II | 2 | 1 | 0 | 1 | 3:10 | -7 | 3 |
| 11 |
|
RWDM Brussels FC II | 2 | 0 | 1 | 1 | 3:4 | -1 | 1 |
| 12 |
|
KVC Westerlo II | 2 | 0 | 0 | 2 | 0:2 | -2 | 0 |
| 13 |
|
Lommel SK II | 2 | 0 | 0 | 2 | 3:6 | -3 | 0 |
| 14 |
|
KV Kortrijk II | 2 | 0 | 0 | 2 | 0:3 | -3 | 0 |
| Promotie |
