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| U | Patriotas FC | - | Atlético Huila | 1:1 (1:0) | ||
| R | Atlético Huila | - | Patriotas FC | 3:1 (0:0, 0:0) d.p. | ||
| U: 13.05.2018 01:00 | R: 20.05.2018 03:00 | Winnaars: Atlético Huila | ||||
| U | Deportivo Cali | - | Atlético Nacional | 1:0 (0:0) | ||
| R | Atlético Nacional | - | Deportivo Cali | 2:0 (0:0) | ||
| U: 13.05.2018 03:00 | R: 20.05.2018 01:00 | Winnaars: Atlético Nacional | ||||
| U | Atlético Junior | - | Independiente Medellín | 0:1 (0:0) | ||
| R | Independiente Medellín | - | Atlético Junior | 2:2 (1:1) | ||
| U: 14.05.2018 00:15 | R: 21.05.2018 02:30 | Winnaars: Independiente Medellín | ||||
| U | Once Caldas | - | Deportes Tolima | 1:0 (0:0) | ||
| R | Deportes Tolima | - | Once Caldas | 3:0 (1:0) | ||
| U: 14.05.2018 02:30 | R: 21.05.2018 00:15 | Winnaars: Deportes Tolima | ||||
