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| 02.07.2021 | 17:00 | Ceramica Cleopatra | - | Aswan SC | 1:1 (0:0) | |
| 19:00 | El Entag El Harby | - | El Gouna | 1:1 (1:1) | ||
| 21:00 | National Bank SC | - | Al Masry Club | 2:0 (1:0) | ||
| 04.07.2021 | 17:00 | Al Mokawloon | - | Tala'ea El Gaish SC | 0:1 (0:0) | |
| 19:00 | Pyramids FC | - | ENPPI | 1:1 (1:1) | ||
| 21:00 | Smouha Sporting Club | - | Al Ahly SC | 0:4 (0:3) | ||
| 05.07.2021 | 17:00 | Wadi Degla SC | - | Misr lel-Maqasah SC | 1:1 (0:1) | |
| 19:00 | Ismaily | - | Ittihad El Iskandary | 1:2 (0:0) | ||
| 07.08.2021 | 19:00 | Zamalek | - | Ghazl Al Mehalla | 3:0 (3:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Al Ahly SC | 28 | 19 | 7 | 2 | 60:22 | 38 | 64 |
| 2 |
|
Zamalek | 28 | 19 | 7 | 2 | 51:18 | 33 | 64 |
| 3 |
|
Al Masry Club | 28 | 11 | 10 | 7 | 37:29 | 8 | 43 |
| 4 |
|
Pyramids FC | 28 | 9 | 15 | 4 | 41:34 | 7 | 42 |
| 5 |
|
Ittihad El Iskandary | 28 | 11 | 8 | 9 | 33:32 | 1 | 41 |
| 6 |
|
Smouha Sporting Club | 28 | 8 | 16 | 4 | 43:37 | 6 | 40 |
| 7 |
|
ENPPI | 28 | 9 | 11 | 8 | 31:30 | 1 | 38 |
| 8 |
|
Tala'ea El Gaish SC | 28 | 10 | 7 | 11 | 37:31 | 6 | 37 |
| 9 |
|
Misr lel-Maqasah SC | 28 | 10 | 7 | 11 | 29:37 | -8 | 37 |
| 10 |
|
El Gouna | 28 | 8 | 12 | 8 | 29:30 | -1 | 36 |
| 11 |
|
Ceramica Cleopatra | 28 | 7 | 12 | 9 | 35:39 | -4 | 33 |
| 12 |
|
Ismaily | 28 | 9 | 9 | 10 | 37:35 | 2 | 33 |
| 13 |
|
Ghazl Al Mehalla | 28 | 7 | 11 | 10 | 22:32 | -10 | 32 |
| 14 |
|
Al Mokawloon | 28 | 7 | 8 | 13 | 27:37 | -10 | 29 |
| 15 |
|
National Bank SC | 28 | 5 | 12 | 11 | 29:36 | -7 | 27 |
| 16 |
|
Aswan SC | 28 | 6 | 7 | 15 | 22:48 | -26 | 25 |
| 17 |
|
Wadi Degla SC | 28 | 4 | 11 | 13 | 25:35 | -10 | 23 |
| 18 |
|
El Entag El Harby | 28 | 3 | 10 | 15 | 27:53 | -26 | 19 |
| Champions League | |
| Confederation Cup | |
| Degradatie |
