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| 06.04.2022 | 14:00 | Niki Volou FC | - | PAOK Saloniki II | 2:1 (1:0) | |
| 14:00 | Almopos Arideas | - | AO Trikala | 3:0 (2:0) | ||
| 14:00 | AO Kavala | - | AE Lárissa | 0:1 (0:1) | ||
| 14:00 | Thesprotos | - | Apollon Lárissa | 1:1 (1:1) | ||
| 14:00 | Xanthi FC | - | Olympiakos Piraeus II | 2:1 (1:0) | ||
| 14:00 | Pierikos Katerini | - | Panserraikos | 1:1 (1:1) | ||
| 14:00 | Anagennisi Karditsa | - | AEP Iraklis FC | 0:3 (0:1) | ||
| 14:00 | Apollon Pontou | - | Veria FC | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Veria FC | 27 | 20 | 5 | 2 | 53:19 | 34 | 65 |
| 2 |
|
AE Lárissa | 27 | 17 | 8 | 2 | 36:11 | 25 | 59 |
| 3 |
|
Xanthi FC | 27 | 12 | 11 | 4 | 38:17 | 21 | 47 |
| 4 |
|
Niki Volou FC | 27 | 13 | 8 | 6 | 34:17 | 17 | 47 |
| 5 |
|
Anagennisi Karditsa | 28 | 13 | 5 | 10 | 39:29 | 10 | 44 |
| 6 |
|
Almopos Arideas | 27 | 10 | 8 | 9 | 36:26 | 10 | 38 |
| 7 |
|
Olympiakos Piraeus II | 27 | 10 | 8 | 9 | 30:28 | 2 | 38 |
| 8 |
|
AEP Iraklis FC | 27 | 8 | 13 | 6 | 31:23 | 8 | 37 |
| 9 |
|
PAOK Saloniki II | 28 | 8 | 11 | 9 | 30:29 | 1 | 35 |
| 10 |
|
Apollon Pontou | 28 | 8 | 9 | 11 | 31:34 | -3 | 33 |
| 11 |
|
Thesprotos | 27 | 7 | 9 | 11 | 30:30 | 0 | 30 |
| 12 |
|
Pierikos Katerini | 28 | 6 | 10 | 12 | 30:41 | -11 | 28 |
| 13 |
|
Apollon Lárissa | 27 | 6 | 10 | 11 | 21:36 | -15 | 28 |
| 14 |
|
AO Kavala | 27 | 6 | 8 | 13 | 22:66 | -44 | 26 |
| 15 |
|
Panserraikos | 27 | 5 | 10 | 12 | 28:36 | -8 | 25 |
| 16 |
|
Olympiakos Volou | 27 | 5 | 7 | 15 | 27:43 | -16 | 22 |
| 17 |
|
AO Trikala | 28 | 5 | 6 | 17 | 17:48 | -31 | 21 |
| Play-offs | |
| Degradatie |
