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| 22.02.2022 | 14:30 | ACR Messina | - | SS Monopoli 1966 | 2:1 (1:0) | |
| 18:00 | Campobasso | - | Monterosi FC | 1:2 (0:0) | ||
| 18:00 | Latina Calcio | - | US Avellino | 0:0 (0:0) | ||
| 21:00 | Calcio Catania | - | Paganese Calcio | geannuleerd | ||
| 21:00 | SS Juve Stabia | - | Vibonese Calcio | 3:1 (0:0) | ||
| 21:00 | Potenza | - | US Catanzaro | 0:0 (0:0) | ||
| 21:00 | SSC Bari | - | AZ Picerno | 1:0 (0:0) | ||
| 21:00 | FC Turris | - | Foggia Calcio | 3:1 (2:1) | ||
| 21:00 | Virtus Francavilla | - | Fidelis Andria | 1:0 (1:0) | ||
| 30.03.2022 | 14:30 | Palermo FC | - | Taranto FC | 5:2 (3:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSC Bari | 21 | 14 | 5 | 2 | 36:14 | 22 | 47 |
| 2 |
|
US Avellino | 21 | 9 | 11 | 1 | 26:13 | 13 | 38 |
| 3 |
|
Virtus Francavilla | 21 | 12 | 2 | 7 | 26:17 | 9 | 38 |
| 4 |
|
Palermo FC | 21 | 10 | 7 | 4 | 32:18 | 14 | 37 |
| 5 |
|
US Catanzaro | 21 | 9 | 8 | 4 | 28:14 | 14 | 35 |
| 6 |
|
SS Monopoli 1966 | 20 | 10 | 4 | 6 | 23:17 | 6 | 34 |
| 7 |
|
FC Turris | 21 | 10 | 3 | 8 | 37:24 | 13 | 33 |
| 8 |
|
Foggia Calcio | 21 | 7 | 9 | 5 | 31:25 | 6 | 30 |
| 9 |
|
AZ Picerno | 21 | 8 | 5 | 8 | 21:25 | -4 | 29 |
| 10 |
|
Taranto FC | 21 | 7 | 7 | 7 | 23:26 | -3 | 28 |
| 11 |
|
SS Juve Stabia | 21 | 7 | 8 | 6 | 25:24 | 1 | 27 |
| 12 |
|
Latina Calcio | 21 | 7 | 5 | 9 | 23:26 | -3 | 26 |
| 13 |
|
Monterosi FC | 21 | 5 | 9 | 7 | 20:27 | -7 | 24 |
| 14 |
|
Campobasso | 21 | 5 | 6 | 10 | 23:36 | -13 | 21 |
| 15 |
|
ACR Messina | 21 | 5 | 5 | 11 | 23:36 | -13 | 20 |
| 16 |
|
Potenza | 21 | 4 | 7 | 10 | 16:27 | -11 | 19 |
| 17 |
|
Paganese Calcio | 20 | 5 | 3 | 12 | 21:36 | -15 | 18 |
| 18 |
|
Fidelis Andria | 20 | 4 | 4 | 12 | 17:31 | -14 | 16 |
| 19 |
|
Vibonese Calcio | 21 | 2 | 8 | 11 | 15:30 | -15 | 14 |
| 20 |
|
Calcio Catania | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
