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| 03.04.2022 | 15:00 | ASG Nocerina | - | Città di Fasano | 0:2 | |
| 15:00 | US Bitonto | - | Casertana FC | 0:2 | ||
| 15:00 | Brindisi | - | FBC Gravina | 1:0 | ||
| 15:00 | FC Francavilla | - | ACD Nardò | 3:2 | ||
| 15:00 | Mariglianese | - | Audace Cerignola | 0:3 | ||
| 15:00 | Sporting Fulgor Molfetta | - | ASD SS Nola 1925 | 0:3 | ||
| 15:00 | Rotonda | - | Bisceglie | 2:0 | ||
| 15:00 | San Giorgio-Sedico | - | Team Altamura | 1:2 | ||
| 15:00 | Sorrento Calcio | - | Casarano | 3:0 | ||
| 15:00 | Virtus Matino | - | Lavello | 1:2 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Audace Cerignola | 31 | 20 | 9 | 2 | 67:24 | 43 | 69 |
| 2 |
|
FC Francavilla | 31 | 19 | 4 | 8 | 50:33 | 17 | 61 |
| 3 |
|
US Bitonto | 31 | 16 | 8 | 7 | 47:33 | 14 | 56 |
| 4 |
|
Città di Fasano | 31 | 15 | 7 | 9 | 54:39 | 15 | 52 |
| 5 |
|
ASG Nocerina | 31 | 14 | 6 | 11 | 43:39 | 4 | 48 |
| 6 |
|
Casertana FC | 31 | 13 | 8 | 10 | 49:44 | 5 | 47 |
| 7 |
|
FBC Gravina | 31 | 14 | 5 | 12 | 40:40 | 0 | 47 |
| 8 |
|
Sorrento Calcio | 31 | 13 | 8 | 10 | 36:37 | -1 | 47 |
| 9 |
|
Sporting Fulgor Molfetta | 31 | 10 | 12 | 9 | 39:34 | 5 | 42 |
| 10 |
|
ASD SS Nola 1925 | 31 | 11 | 7 | 13 | 39:45 | -6 | 40 |
| 11 |
|
Team Altamura | 31 | 9 | 11 | 11 | 38:35 | 3 | 38 |
| 12 |
|
Lavello | 31 | 10 | 8 | 13 | 43:47 | -4 | 38 |
| 13 |
|
Brindisi | 31 | 10 | 7 | 14 | 27:42 | -15 | 37 |
| 14 |
|
Casarano | 31 | 9 | 9 | 13 | 31:42 | -11 | 36 |
| 15 |
|
ACD Nardò | 31 | 9 | 8 | 14 | 40:52 | -12 | 35 |
| 16 |
|
San Giorgio-Sedico | 31 | 8 | 9 | 14 | 22:32 | -10 | 33 |
| 17 |
|
Rotonda | 31 | 11 | 7 | 13 | 31:35 | -4 | 32 |
| 18 |
|
Mariglianese | 31 | 8 | 7 | 16 | 32:40 | -8 | 31 |
| 19 |
|
Bisceglie | 31 | 5 | 14 | 12 | 24:40 | -16 | 29 |
| 20 |
|
Virtus Matino | 31 | 6 | 6 | 19 | 27:46 | -19 | 24 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
